Chromosomal translocations represent frequent events in leukemia. In t(8;21)+ acute myeloid leukemia, RUNX1 is fused to nearly the entire ETO protein, which contains four conserved, NHR1-4. Furthermore RUNX1/ETO interacts with ETO-homologous proteins via NHR2, thereby multiplying NHR domain ...
The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine kinas
The significance of a permissive window is ironically best shown by a large number of failures in generating the animal model for acute myeloid leukemia (AML) with t(8;21). Over the decades, the RUNX1-ETO fusion gene created by t(8;21) has been introduced into various types of ...
RUNX1T1/MTG8/ETO gene expression status in human t(8;21)(q22;q22)-positive acute myeloid leukemia cells The RUNX1- RUNX1T1 fusion gene, a product of the n Ramanouskaya,V T.,Migas,... - 《Leukemia Research A Forum for Studies on Leukemia & Normal Hemopoiesis》 被引量: 9发表: 2014...
Figure 3. RUNX1 Fusion Proteins Form Part of a Gene Regulatory Network Unique to Each Leukemia (A) UCSC genome browser screen shot of Spi1 showing ChIP-seq data of RUNX1 and RUNX1-EVI1 from t(3;21) SKH-1 cells, RUNX1 and RUNX1-ETO from t(8;21) Kasumi-1 cells, and RUNX1 from...
RUNX1 Runt-related transcription factor 1 AML1 acute myeloid leukemia 1 C11orf21 chromosome 11 open reading frame 21 1. Introduction The Runt-related transcription factor 1 (RUNX1) gene was initially identified from the breakpoint on chromosome 21 [1]. RUNX1 is known as an essential transcript...
(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to...
RUNX1T1 is a putative transcription factor which forms a heterodimer with CBFA2T3. Defects in RUNX1T1 have been associated with acute myeloid leukemia (AML-M2) and may be a cause of colorectal cancer. Anti-AML-ETO Antibody is ideal for research in Gene Expression and Cancer. ...
Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukemia (AML), they are common in murine models of radiat... S Basilico,FC Nieto,B Gottgens - 《Experimental Hematology》 被引量: 0发表: 2016年 Recent letters It is well accepted that ...
Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML). These translocations often occur in critical transcriptional/epigenetic regulators and contribute to malignant cell growth through alteration of normal gene expression. Despite this knowledge, the specific gen...