AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with ...
To elucidate mechanisms by which RUNX1–ETO, the common acute myeloid leukemia t(8;21) fusion protein, primes hematopoietic cells for oncogenic transformation, we previously carried out Affymetrix gene expression profiling of RUNX1–ETO-expressing human CD34+progenitor cells.1We identified the MYC tar...
The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine kinas
混合系列白血病(mixed lineage leukemia,MLL)基因,即MLL基因可以发生自身串联重复(dupMLL),也可以和其他伙伴基因发生重排形成融合基因,例如与细胞核蛋白基因(AF4,AF9,AF10等)重排形成MLL-AF4、MLL-AF9融合基因。MLL基因突变通常具有单核细胞分化特征,且由于白血病细胞兼具髓系和淋巴系免疫学标志表达,因而被称为混合...
acute myeloid leukemiaRUNX1/ETOepigenetic regulationchromatinintegrated analysis of high-throughput dataThe t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription ...
(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to...
RUNX1::RUNX1T1AML1-ETO21AML1融合基因(也称)是由号染色体的基因与8号染色体的ETO基因融合形成,于1990年早期被发现,其产物是一种转录抑制因子,可抑制正常AML1蛋白介导的功能,改变造血祖细胞自我更新及成[1,2]熟过程,同时也产生启动异常造血细胞增殖的信号,引起白血病细胞的生长。acutemyeloidleukemia,...
Acute Myeloid Leukemia witht(8;21)(q22;q22.1);RUNX1-RUNX1T1 查宏斌,陈红梅,夏成青 更新时间:2018-04-23 11:24:00 概述: 急性髓系白血病伴t(8;21)(q22;q22.1);RUNX1-RUNX1T1在形态学上通常有粒系的分化成熟,诊断系根据其特有的遗传学改变,极少数病例母细胞计数可以低于20%。此型白血病完全缓解率...
RUNX1T1 is a putative transcription factor which forms a heterodimer with CBFA2T3. Defects in RUNX1T1 have been associated with acute myeloid leukemia (AML-M2) and may be a cause of colorectal cancer. Anti-AML-ETO Antibody is ideal for research in Gene Expression and Cancer. ...
RUNX1-ETO9a/Rassf2 primary leukemia model Transfections of HEK293T cells were conducted by combining 2.5 μg of MSCV-IRES-GFP or MSCV-RUNX1-ETO9a-IRES-GFP retroviral expression vector, 2.5 μg of MSCV-IRES-tdTomato or MSCV-Rassf2-IRES-tdTomato, along with packaging components. For ...