AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with ...
In t(8;21)+ acute myeloid leukemia, RUNX1 is fused to nearly the entire ETO protein, which contains four conserved, NHR1-4. Furthermore RUNX1/ETO interacts with ETO-homologous proteins via NHR2, thereby multiplying NHR domain contacts. As shown recently, RUNX1/ETO retains oncogenic activity...
The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine kinas
混合系列白血病(mixed lineage leukemia,MLL)基因,即MLL基因可以发生自身串联重复(dupMLL),也可以和其他伙伴基因发生重排形成融合基因,例如与细胞核蛋白基因(AF4,AF9,AF10等)重排形成MLL-AF4、MLL-AF9融合基因。MLL基因突变通常具有单核细胞分化特征,且由于白血病细胞兼具髓系和淋巴系免疫学标志表达,因而被称为混合...
AML1/ETOCholinesteraseChromosomal translocationHematopoietic malignanciesRunx1/AML1TranscriptionRunx1/AML1, a chromosome 21q22 hematopoietic regulator, is frequently translocated in leukemia. Its protein product, a relatively weak transcriptional activator, becomes an effective transcriptional enhancer or repressor...
RUNX1T1/MTG8/ETO gene expression status in human t(8;21)(q22;q22)-positive acute myeloid leukemia cells The RUNX1- RUNX1T1 fusion gene, a product of the n Ramanouskaya,V T.,Migas,... - 《Leukemia Research A Forum for Studies on Leukemia & Normal Hemopoiesis》 被引量: 9发表: 2014...
(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to...
Acute Myeloid Leukemia witht(8;21)(q22;q22.1);RUNX1-RUNX1T1 查宏斌,陈红梅,夏成青 更新时间:2018-04-23 11:24:00 概述: 急性髓系白血病伴t(8;21)(q22;q22.1);RUNX1-RUNX1T1在形态学上通常有粒系的分化成熟,诊断系根据其特有的遗传学改变,极少数病例母细胞计数可以低于20%。此型白血病完全缓解率...
RUNX1-ETO9a/Rassf2 primary leukemia model Transfections of HEK293T cells were conducted by combining 2.5 μg of MSCV-IRES-GFP or MSCV-RUNX1-ETO9a-IRES-GFP retroviral expression vector, 2.5 μg of MSCV-IRES-tdTomato or MSCV-Rassf2-IRES-tdTomato, along with packaging components. For ...
RUNX1 was originally identified in acute myeloid leukemia (AML) patients with t(8;21), where the fusion with the ETO gene impairs its function [43–46]. During mouse development, Runx1 is expressed in specific subsets of endothelial cells in all embryonic and extraembryonic hematopoietic sites,...