Monogenic ocular diseases are good candidates for gene transfer therapy, as the eye has favourable anatomical and immunological characteristics, providing a contained physical space protected by the blood-ocular barrier that is particularly suited for local delivery [14]. Remarkably, RPE65-associated IRD...
scale in adults:apreliminary study[J].J Exerc Sci Fit,2008,29(1): 44-49. [20]Eston R G,Parfitt C G,Campbell L,et al.Reliability of effort perception for regulating exercise intensity in children using the Cart and Load Effort Rating(CALER)Scale[J].Pediatr Exerc Sci,2000(12): 388-...
Scale bars 200 µm (B), 50 µm (C,E). Full size image Replacement of RPEs by mimicked hiPSC-RPE transplantation by cell suspension or an RPE-strip in the in vitro RPE damaged model In order to investigate the way in which transplantation of hiPSC-RPE strips or cells could ...
Several clinical studies have been conducted into the practicality and safety of regenerative therapy using hESC/iPSC-retinal pigment epithelium (RPE) as a treatment for the diseases including age-related macular degeneration. These studies used either suspensions of RPE cells or an RPE cell sheet. ...
(Scale bar = 20 µm) (n = 1).BConfocal microscopy analyses of RPE wholemounts obtained from the same CLN3 disease and control donor eyes (as were shown in panelA) showed decreased autofluorescence (measured in red channel) in areas with intact RPE monolayer. Of note, light ...
Figure 5. Potential of patient-specific iPSC-derived RPEs for large-scale production. Patient-derived iPSCs can be easily obtained from patients’ somatic cells and expanded infinitely in culture, allowing the large-scale production of iPSC-derived RPEs to meet the demand of disease modeling, patho...