Scale bars, 30 μm (a) and 100 μm (e) Full size image Discussion In this study, we showed that the downregulation of TXNIP causes RPE cell dysfunction via at least three pathways: (1) the induction of RPE cell autophagy through p53-mediated AMPK activation; (2) an increase in ...
The horizontal timescale is 50 ms per division. ERG analysis in affected members of the extended TCD-G family showed impairment of rod function, even in mildly affected indivi- duals. In more severely affected individuals, rod-isolated responses are either severely attenuated or non-recordable (...
Scale bar: 50 μm **P < 0.01, *P < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.) 2.6. DAPL1 up-regulates MITF by down-regulating MYC in RPE cells Given that the cell cycle regulator MYC ...
Figure 4. Line graph showing mean visual acuity (VA) using Holladay scale, averaged over both eyes (modified intention-to-treat population). Data presented as mean ± standard error. BL = baseline; D = day; logMAR = logarithm of the minimum angle of resolution; X = crossover; XY1 = de...
Fifteen out of 18 patients gained visual acuity, with a mean of > 7 lines on the logMar scale. In one patient the visual acuity was unaffected. Two patients suffered a drop in visual acuity. In all but two patients, central fixation on the graft, as tested with the slitlamp set to ...