Reactive oxygen species (ROS) are also mediators that induce cell death, but their roles in TRAIL-induced apoptosis have not been elucidated fully. In the current study, we investigated ROS and caspases in human pancreatic cancer cells undergoing two different types of TRAIL-induced cell death, ...
The roles of ROS and caspases in TRAIL-induced apoptosis and necroptosis in human pancreatic cancer cells. PloS one 10: p.e0127386.Zhang, M.; Harashima, N.; Moritani, T.; Huang, W.; Harada, M. The roles of ROS and caspases in TRAIL-induced apoptosis and necroptosis in human ...
54 In a related example, GPX4 inhibition can sensitize cancer cells to apoptosis induced by second mitochondrial-derived activator of caspases (SMAC) mimetics,77 connecting ferroptosis to apoptotic cell death pathways. Although more work is required to define these links, given the possibility that ...
Using caspase inhibitors, it was found that caspases were specifically involved in ATP-induced apoptotic damage such as chromatin condensation and \{DNA\} fragmentation. In contrast, inhibition of caspases only marginally affected necrotic alterations and cell death proceeded normally whether or not ...
Using caspase inhibitors, it was found that caspases were specifically involved in ATP-induced apoptotic damage such as chromatin condensation and DNA fragmentation. In contrast, inhibition of caspases only marginally affected necrotic alterations and cell death proceeded normally whether or not nuclear ...
Apoptosis occurs during the development,aging,and in various disease states.The apoptotic biochemicalcascade involves activation of caspases,release of mitochondrial apoptotic factors,and nuclear DNAfragmentation,subjecting to regulation by pro-and anti-apoptotic Bcl-2 genes.Emerging evidence supportsthat apop...
form apoptosomes, which in turn activate the initiator caspase-9. Crosstalk between the extrinsic and intrinsic pathways can occur through BID cleavage by caspase-8, leading to activation of BAX and BAK. The two pathways converge at activation of the effector caspases (caspase-3 and caspase-7)...
According to the NCCD's definition, pyroptosis is frequently but not always regulated by the activation of caspases, and is dependent on the gasdermin protein family for pore formation in the cytoplasmic membrane. This is in contrast to the appealing form of cell death [12]. Cells swell, the...
compounds or treatment with bacterial sphingomyelinase, induced predominantly necrotic rather than apoptotic cell death in A20 B-, Raji B- and Jurkat T-... Hetz,A C. - 《Journal of Cell Science》 被引量: 243发表: 2002年 Caspases are the main executioners of Fas-mediated apoptosis, irrespe...
Necroptosis is a form of regulated lytic cell death that operates independent of caspases, and requires both RIPK3 and MLKL function (Fig. 2). It is important to note that although the studies discussed below have specified necroptosis as the specific cell death outcome involved in the ...