However, as is clear from the worm studies, the evolutionarily conserved role of caspases is to execute programmed cell death. In this article, I will specifically focus on caspases that function primarily in cell death execution. In particular, the physiological function of caspases in apoptosis ...
Ultimately, apoptotic cells are ingested by neighboring cells and phagocytes, preventing inflammation and tissue damage that might ensue upon cell-lysis. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the...
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death[J]. Science, 2018, 362(6418):1064-1069. [21]KELLER N, OZMADENCI D, ICHIM G, et al. Caspase-8 function, and phosphorylation, in cell m...
Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably the main form of β-cell death in both forms of the dise... M Cnop,N Welsh,JC Jonas,... - 《Diabetes》 被引量: 2087发表: 2005年 Caspase function in programmed cell death The first pro...
In addition, various caspase inhibitors block plant programmed cell death (PCD), suggesting that the proteases involved are required for completion of the process. Yet plants do not have caspase orthologous genes in their genomes, and the proteases phylogenetically closest to caspases, the metacaspase...
Programmed cell death is essential part of development and cell homeostasis of any multicellular organism. We have analyzed programmed cell death in developing barley caryopsis at histological, biochemical and molecular level. Caspase-1, -3, -4, -6 and -8-like activities increased with aging of ...
Three groups of caspase-like proteases: metacaspases, legumain family proteases (VPEs) and saspases have been identified and characterized in plants so far. A considerable amount of evidence supports the role of these enzymes in programmed cell death (PCD) occurring during plant development, their...
Caspase-9 takes part in programmed cell death in developing mouse kidney. Authors:Araki, Takashi and Hayashi, Matsuhiko and Nakanishi, Keiko and Morishima, Nobuhiro and Saruta, Takao Journal:Nephron. Experimental nephrology (2003): e117-24 ...
S. Kumar Caspase function in programmed cell death Cell Death Differ., 14 (2007), pp. 32-43 CrossrefView in ScopusGoogle Scholar Lei et al., 2012 Y. Lei, H. Wen, Y. Yu, D.J. Taxman, L. Zhang, D.G. Widman, K.V. Swanson, K.W. Wen, B. Damania, C.B. Moore, et al. ...
Inflammasome Activators Induce Interleukin-1alpha Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1: O. Gross, et al.; Immunity36,388 (2012) Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activati...