As reviewed in other articles in this issue of Cell Death and Differentiation, many caspases function in nonapoptotic pathways. However, as is clear from the worm studies, the evolutionarily conserved role of caspases is to execute programmed cell death. In this article, I will specifically focus...
Ultimately, apoptotic cells are ingested by neighboring cells and phagocytes, preventing inflammation and tissue damage that might ensue upon cell-lysis. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the...
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death[J]. Science, 2018, 362(6418):1064-1069. [21]KELLER N, OZMADENCI D, ICHIM G, et al. Caspase-8 function, and phosphorylation, in cell m...
Three groups of caspase-like proteases: metacaspases, legumain family proteases (VPEs) and saspases have been identified and characterized in plants so far. A considerable amount of evidence supports the role of these enzymes in programmed cell death (PCD) occurring during plant development, their...
Programmed cell death is essential part of development and cell homeostasis of any multicellular organism. We have analyzed programmed cell death in developing barley caryopsis at histological, biochemical and molecular level. Caspase-1, -3, -4, -6 and -8-like activities increased with aging of ...
Moreover, loss of the soma-specific (CSP-3) and germline-specific (CSP-2) caspase inhibitors result in CED-3-dependent suppression of embryonic lethality and meiotic chromosome non-disjunction respectively, when separase function is compromised. Thus, while caspases and separases have evolved ...
Supporting this hypothesis, we show that elimination of DIAP1 function results in global early embryonic cell death and a large increase in DIAP1-inhibitable caspase activity and that DIAP1 is still required for cell survival when expression of rpr, hid, and grim is eliminated....
Caspase-9 takes part in programmed cell death in developing mouse kidney. Authors:Araki, Takashi and Hayashi, Matsuhiko and Nakanishi, Keiko and Morishima, Nobuhiro and Saruta, Takao Journal:Nephron. Experimental nephrology (2003): e117-24 ...
首先呢,它是一种细胞程序性死亡 (Programmed Cell Death, PCD),即细胞接受某种信号或受到某些因素刺激后,为了维持内环境稳定,按照预定的程序发生的一种主动性消亡过程。也就是说,这是完全自愿的高尚牺牲! 程序性细胞死亡主要包括:程序性坏死(Necroptosis)、凋亡(Apoptosis)、细胞焦亡(Pyroptosis)和铁死亡(Ferroptosis)等...
S. Kumar Caspase function in programmed cell death Cell Death Differ., 14 (2007), pp. 32-43 CrossrefView in ScopusGoogle Scholar Lei et al., 2012 Y. Lei, H. Wen, Y. Yu, D.J. Taxman, L. Zhang, D.G. Widman, K.V. Swanson, K.W. Wen, B. Damania, C.B. Moore, et al. ...