2. Boucher, Dave et al. “Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.” The Journal of experimental medicine vol. 215,3 (2018): 827-840. doi:10.1084/jem.20172222 3. Ball, Daniel P et al. “Caspase-1 interdomain linker cleavage is required for py...
英文名称Caspase1ActivityAssayKit 别名Caspase1活性测定试剂盒 Caspase-1是*可剪切IL-1b和IL-18前体产生活性细胞因子的caspase。Caspase-11剪切45kD的caspase-1前体蛋白产生20kD和10kD片断,这两个片断可以形成异源二聚体,并进一步形成四聚体。 描述:细胞凋亡属于程序化细胞死亡,可见于各种器官和细胞,在正常发育、生理...
Caspase 1活性检测试剂盒(Caspase1ActivityAssayKit)是采用分光光度法检测细胞或组织裂解液中caspase 1酶活性或纯化的caspase 1酶活性的试剂盒。 Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。Caspase 1也称interkeukin 1bconbertingenzyme(ICE),有时被写作caspase-1或...
2013. Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop. Front. Cell. Infect. Microbiol. 3:14. http://dx.doi... C Juruj,V Lelogeais,R Pierini,... - 《Front Cell Infect Microbiol》 被引量: 7发表: 2014年 Caspase-1 activity affects AIM2 speck...
The activity of caspase-1 is increased in lesional psoriatic epidermis. J Invest Dermatol. 2007;127:2857–64.Johansen Claus,Moeller Kristine,Kragballe Knud,Iversen Lars.The activity of caspase-1 is increased in lesional psoriatic epidermis. The Journal of investigative dermatology . 2007...
the administration of FGF21 alleviated VILI in both mouse and cell models. FGF21 reduced Caspase-1 activity, suppressed the mRNA levels ofNlrp3,Asc, Il-1β, Il-18, Hmgb1andNf-κb, and decreased the protein levels of NLRP3, ASC, IL-1β, IL-18, HMGB1 and the cleaved form of GSDMD....
20Altmetric Metrics Abstract The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members ...
Objective To investigate the caspase-1 dependent inflammatory pathway activity and interleukin-1β (IL-1β) secretion in murine macrophage cell lines J774G8 infected with Leishmania major (L. major) using caspase-1 activity assay and ELISA. Methods Novy-MacNeal-Nicolle biphasic medium was applied...
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol.3,14 (2013) Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem.288,35886 (2013) ...
In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity. We found that DG administration decreased infarct size and cardiomyocyte apoptosis and improved left ventricular ejection fraction, fractional shortening, ...