Caspase 1活性检测试剂盒(Caspase1ActivityAssayKit)是采用分光光度法检测细胞或组织裂解液中caspase 1酶活性或纯化的caspase 1酶活性的试剂盒。 Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。Caspase 1也称interkeukin 1bconbertingenzyme(ICE),有时被写作caspase-1或...
英文名称Caspase1ActivityAssayKit 别名Caspase1活性测定试剂盒 Caspase-1是*可剪切IL-1b和IL-18前体产生活性细胞因子的caspase。Caspase-11剪切45kD的caspase-1前体蛋白产生20kD和10kD片断,这两个片断可以形成异源二聚体,并进一步形成四聚体。 描述:细胞凋亡属于程序化细胞死亡,可见于各种器官和细胞,在正常发育、生理...
Caspase-1 activity was measured in monocytes and neutrophils by flow cytometry detecting FLICA (fluorescent-labeled inhibitor of caspase-1), while IL-1尾 and IL-18 was measured by Luminex and ELISA, respectively. As a measure of inflammasome priming, messenger RNA (mRNA) expression of NLRP3, ...
Although caspase-1 is a key participant in inflammation, there is no sensitive assay to measure its enzymatic activity in real time in cells or animals. Here we describe a nanosensor for caspase-1 ratiometric measurements, consisting of a rhodamine-labeled, caspase-1 cleavable peptide linked to...
Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown. Caspase-1 is activated on inflammasomes, signaling platforms that facilitate caspase-1 dimerization and autoprocessing. Previous studies with...
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol.3,14 (2013) Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem.288,35886 (2013) ...
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity. Eur. J. Immunol. 38, 2085–2089 (2008). CAS PubMed PubMed Central Google Scholar Kool, M. et al. Cutting Edge: alum adjuvant stimulates inflammatory dendritic cells ...
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In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity. We found that DG administration decreased infarct size and cardiomyocyte apoptosis and improved left ventricular ejection fraction, fractional shortening, ...
TRXR and inflammasome activity promoted filopodia formation, cellular release of reduced TRX, and generation of extracellular thiol pathway-dependent, procoagulant microparticles (MPs). Additionally, inflammasome-induced activation of an intracellular caspase-1/calpain cysteine protease cascade degraded filamin,...