Widespread MOMP effectively acts as cellular death sentence; usually it leads to caspase activation and apoptosis however even without caspases, cells die post-MOMP through a process called caspase-independent cell death or CICD. The success of directly targeting apoptosis to treat cancer is perhaps...
Caspase activation has been frequently viewed as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects. In a number of different models, caspase inhibition does not...
T lymphocyte death is essential for proper function of the immune system. During the decline of an immune response, most of the activated T cells die. Cell death is also responsible for eliminating autoreactive lymphocytes. Although recent studies have focused on caspase-dependent apoptotic signals,...
Caspase independent cell death : leaving the set without the final cut S Tait - 《Oncogene》 被引量: 0发表: 2008年 The GPI Transamidase Complex of Saccharomyces cerevisiae Contains Gaa1p, Gpi8p, and Gpi16p Gpi8p and Gaa1p are essential components of the GPI transamidase that adds glycosyl...
BerberineInducesCaspase-IndependentCellDeathinColonTumorCellsthroughActivationofApoptosis-InducingFactorLihongWang1,2,LipingLiu1,YanShi1¤a,HanweiCao1¤b,RupeshChaturvedi3,M.WadeCalcutt4,TianhuiHu2,XiubaoRen5,KeithT.Wilson3,6,7,D.BrentPolk8,FangYan1,5*1DepartmentofPediatrics,VanderbiltUniversityMedicalCe...
Taylor & Francis Online :: FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells - Autophagy - Volume 7, Issue 7 Acute lymphoblastic leukemia (ALL), the most common form of childhood cancer, usually responds to chemotherapy but patients who develop disease relapse have...
Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because mitochondria-enriched fractions were found to be necessary for activation of death proteases, the caspases, in a cell-free model of ...
Both caspase-dependent and caspase-independent cell death executors participate in yeast cell death. On one hand, a yeast caspase-like protease appears to be essential for approximately 40% of the investigated cell death scenarios. On the other hand, factors like the mitochondrially located ...
PML induces a novel caspase-independent death process.PML nuclear bodies (NBs) are nuclear matrix-associated structures altered by viruses and oncogenes. We show here that PML overexpression induces rapid cell death, independent of de novo transcription and cell cycling. PML death involves cytoplasmic...
Cell Death Differ,2003,10(7):798.Yanagisawa H,Miyashita T,Nakano Y,et al.Hsp in1,atransmembrane protein interacting with bcl-2/bcl-xL,in-duces a caspase-independent autophagic cell death.Cell Death and Differentiation. 2003Yanagisawa H, Miyashita T, Nakano Y, Yamamoto D: HSpin1, a ...