Role of NRF2 in Lung Cancerdoi:10.3390/CELLS10081879Miriam Sánchez-OrtegaAna Clara CarreraAntonio GarridoMultidisciplinary Digital Publishing Institute
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients wh...
Acute lung injuryOxidative stressNrf2AutophagyAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. Characterized by severe inflammation and compromised lung function, ALI/ARDS result in very high mortality of...
ZNRF2 belongs to ubiquitin ligases of the RING superfamily, and has been recently shown to be regulated by Akt to interact with a Mechanistic target of rapamycin (mTor). Nevertheless, a role of ZNRF2 in tumorigenesis, especially in non-small cell lung cancer (NSCLC), is unknown. Here, we...
The tumour suppressor gene p53 is one of the most frequently mutated genes in lung cancer and these defects are associated with poor prognosis, albeit some debate exists in the lung cancer field. Despite extensive research, the exact mechanisms by which
We also found that cells with wild type NrF2 gene had 20-30% induction of promoter activity with sulforaphane. In cells carrying each of the 6 mutants of the Nrf2 gene, there was a significant attenuation of the basal promoter activity. However, the cells containing the mutant Nrf2 constructs...
The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia. Nrf2 activation mitigates multiple pathogenic processes involved in these neurodegenerative disorders through upregulation of ...
Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS limitat
[162]. Nrf2 indeed displays opposing biological activities during carcinogenesis. Therefore, numerous studies have attempted to reveal the precise role of Nrf2 in lung cancer and have gained certain possible points. In a vinyl carbamate/urethane-induced and KrasG12D-driven genetic lung cancer mouse ...
NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells Article 23 July 2020 Introduction Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are increasingly available and are used in the treatment of patients with non-small...