Nrf2 gene therapyNFE2L2MitochondriaCancer stem cells (CSCs) are subpopulation of tumor mass with exclusive abilities in self-renewing, stemness maintaining, and differentiation into the various non-stem cancer cells to provoke tumorigenesis, metastasis dissemination, drug-resistant, and cancer recurrence....
Role of the Keap1-Nrf2 pathway in cancer. Advances in Cancer Research. 2014; 122C: 281-320.Leinonen HM, Kansanen E, PtiRinen P, et al. Role of the keapl -nrf2 pathway in cancer[J], Adv Cancer Res, 2014, 122: 281-320.
In addition to Nrf2, other transcription factors and transcriptional coactivators can participate to maintain the high antioxidant levels in chemo and radio-resistant cancer cells. The control of expression and function of these molecules has been recently deepened to identify which of these could be ...
When the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor is used in combination with TMZ, a decrease in NRF2 expression increases TMZ-induced autophagy, attenuating cancer cell proliferation [55]. Chrysin, a NRF2 inhibitor, was shown to be able to overcome drug ...
Oxidative stress and cancer: the role of Nrf2. Curr Cancer Drug Targets. 2018;18(6):538–57. Article CAS PubMed Google Scholar Zhang Y, Yang Y, Yu H, Li M, Hang L, Xu X. Apigenin protects mouse retina against oxidative damage by regulating the Nrf2 pathway and autophagy. Oxid Med...
Oxidative stress is the outcome of the imbalances between the generation and disposal of reactive oxygen species (ROS) and is a major causative factor for several chronic diseases such as cancer. Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor, mediates the activation of...
Ferroptosis is an iron- and lipotoxicity-dependent form of regulated cell death (RCD). It is morphologically and biochemically distinct from characteristics of other cell death. This modality has been intensively investigated in recent years due to its i
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer Article Open access 01 March 2024 Broadening horizons: the role of ferroptosis in cancer Article 29 January 2021 INTRODUCTION Over the past decade or so, it has become evident that the free radical gas nitri...
NRF2 knockdown by siRNA resulted increased cell death by Z-Ligustilide in ovarian cancer cells. Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death.doi:10.1016/j.fct.2018.09.041Lang, Fangfang...
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients wh...