Artemisin or derivatives thereof; and a Nrf2 inhibitor according to the present invention cause ferroptosis in cancer cells to induce selective apoptosis of cancer cells; and shows anticancer effects on cancers resistant to cisplatin which is a conventional anticancer agent, and thus may be ...
A low dose stimulation effect could be a risk factor in the role of AITC in cancer prevention and treatment. Isothiocyanates have been shown to activate Nrf2, a master transcription factor involved in cell redox homeostasis, stress adaptation and cytoprotection39. The role of Nrf2 in the low dos...
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell death that is characterized by iron accumulation and lipid peroxida
1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. Aging Cell. 18: e12951 (2019) Article PubMed PubMed Central Google Scholar Chen P, Chen F, Lei J, Zhou B. Gut microbial metabolite urolithin B ...
Thermo-life PA519830 ANTI-NRF2 EA ￥3,613.00 EA Thermo-life PA519832 ANTI-EPCAM EA ￥3,613.00 EA Thermo-life PA519833 ANTI-PI 3 KINASE P85 ALPHA EA ￥3,613.00 EA Thermo-life PA519835 ANTI-DNAJC3 EA ￥3,613.00 EA Thermo-life PA519839 ANTI-PEROXIREDOXIN 6 EA ￥3,613.00 EA Thermo...
Oxidative stress and cancer: Antioxidative role of Ayurvedic plants Ayurvedic plants with antioxidative nature Accumulated evidences suggest that polyphenols of many plants exhibit antioxidant properties by neutralizingfree radicals, quenchingROS, and lowering peroxides.8Most of these plants are widely described...
more effective multi-target agents leading to a reduction in the cancer population worldwide. Below, the potent targets (i.e. highly expressed markers or markers with the expression limited to tumor cells) have been introduced with their respective role in cancer development, progression, and ...
There is still a broad scope to investigate the role of a bioactive component of boswellic acids obtained from various Boswellia species [34]. In the present review, we discussed the individual role as well as the crosstalk of Nrf2, NF-kB cascades that majorly contribute to neuroinflammation, ...
Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators Androgen deprivation therapy (ADT) is the mainstay regimen in patients with androgen-dependent prostate cancer (PCa). However, the selection of androgen-in... D Mondal,D Narwani,S No...
A. The role of itaconate in host defense and inflammation. J. Clin. Invest. https://doi.org/10.1172/jci148548 (2022). Mills, E. L. et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556, 113–117 (2018). Article ADS CAS PubMed ...