Fig. 5. Schematic representation of the dual role of Nrf2 in cancer progression and therapy. 5.3.1. Role of Nrf2 in chemoprevention Nrf2 and HO-1 are upregulated in different types of tumors and correlate with tumor progression, aggressiveness and resistance to therapy. Hu et al. have identif...
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Figure 3. Dual Roles of NRF2 in Cancer The modes of NRF2 regulation during the multistep development of cancer determine its functional outcome and influence the therapeutic intervention that could be used. Controlled activation of NRF2 in normal cells via the canonical mechanism prevents cancer initi...
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Doxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long
When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-...
in the nucleus, whereas ΔN-Nrf2 translocation from the cytoplasm to the nucleus was not observed. Further studies are needed to determine the function of ΔN-Nrf2 in the cytoplasm, in addition to its transcriptional activity, and whether this function is related to carcinogenesis. ...
Herein, this review article will examine the intriguing role of phase separation in activating the NRF2 transcriptional activity and explore the NRF2 dual impacts on tumor immunology, cancer stem cells, metastasis, and long non-coding RNAs (LncRNAs). Taken together, this review aims to discuss the...
Dual roles of Nrf2 in cancer. Pharmacol Res. 2008, 58, 262–270. 43. Yanagawa, T.; Ishikawa, T.; Ishii, T.; Tabuchi, K.; Iwasa, S.; Bannai, S.; Omura, K.; Suzuki, H.; Yoshida, H. Peroxiredoxin I expression in human thyroid tumors. Cancer Lett. 1999, 145, 127–132. 44....
NRF2 has both tumor suppressor and oncogenic roles in cancer, helping to keep cancer from progressing and allowing cancer cells hang on. In many malignancies, its expression is heightened, and it is linked to tumor aggressiveness, progression, and therapeutic resistance [13]. Deregulation of Nrf2 ...