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mainly found in lung cancer, breast cancer, pancreatic cancer, and others. The NRG1 gene fusion leads to abnormal activation of signaling pathways through the ERBB family (especially ERBB3 and ERBB2/HER2), which promotes the growth and differentiation of cancer cells. Therefore, targeted therapies...
[11] Dimou, Anastasios, and D. Ross Camidge. "Detection of NRG1 fusions in solid tumors: Rare gold?" Clinical Cancer Research 25.16 (2019): 4865-4867.[12] Liu, Dawei, and Xinhong Luan. "The Research Progress of Neuregulin 1 in the Reproductive Development." (2015).[13] Newbern, J...
参考文献: 1. Andrew J. Aguirre.OncogenicNRG1fusions: A new hope for targeted therapy inpancreatic cancer.ClinCancerRes. Author manuscript; available in PMC 2020 Feb 1.Published in final edited form as: ClinCancerRes. 2019 Aug 1; 25(15): 4589–4591. Published online 2019 Jun 4. 2. Alex...
[2] Jonna S, Feldman RA, Swenson J, et al. Detection of NRG1 gene fusions in solid tumors. Clin Cancer Res. 2019;25:4966-4972. [3]Daniel R. Carrizosa, Mark E. Burkard, Yasir Y Elamin, et al.CRESTONE: Initial efficacy and...
[5] Jonna S, Feldman RA, Swensen J, et al. Detection of NRG1 gene fusions in solid tumors. Clin Cancer Res. 2019;25:4966-4972. [6] Drilon A, Somwar R, Mangatt BP, et al. Response to ERBB3-directed targeted therapy in NRG1-rearranged cancers. Cancer Discov. 2018;8:686-695....
"Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer." Anti-cancer drugs 28.7 (2017): 717-722.[23] SJonna, Sushma, et al. "Detection of NRG1 gene fusions in solid tumors." Clinical Cancer Research 25.16 (2019): 4966-...
non-small cell lung cancer (NSCLC)target therapyBackground and Objective: Neuregulin 1 (NRG1) is a small ligand of the tyrosine kinase receptors (TKRs) that was recently described as a new molecular trait of non-small cell lung cancer (NSCLC). NRG1 gene rearrangements mainly occur in the ...
1.Gajra A, Klink AJ, Kaufman J, et al. A real-world feasibility study of patients with solid tumors harboring NRG1 gene fusions: NSCLC subset analysis. Presented at: 2020 International Association for the Study of Lung Cancer; January 28-31, 2021; Virtual. Abstract P86.11. ...
NRG1 gene fusions are clinically actionable alterations identified in non-small cell lung cancer (NSCLC) and other tumors. Previous studies have demonstrated that NRG1 fusions signal through HER2/HER3 but thus far strategies targeting HER3 specifically or HER2/HER3 signaling have demonstrated modest ...