signaling and infection ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE Bala Chandran ChakrabortySayanHuman herpesvirus-8 or Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV) is a member of the 纬 2-lymphotropic-oncogenic herpesviruses. KSHV is etiologically associated with Kaposi's sarcoma (KS...
Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver ...
require functional rafts in the growth cone periphery. An extracellular gradient of axon guidance cues can induce growth cone turning by recruiting specific receptors to rafts and activating their downstream signals in a polarized manner. This chapter will examine the role of lipid rafts in mediating...
This book chapter details an innovative in vivo approach to study the crucial role of lipid rafts on the workings of GPCRs in the mouse kidney. This protocol involves the use of a modified mini osmotic pump to deliver an agent that selectively disrupts the lipid raft in the kidney....
Lipid rafts (LRs) play crucial roles in complex physiological processes, modulating innate and acquired immune responses to pathogens. The transmembrane C-type lectins human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and its mouse homolog SIGN-R1 are ...
Our results show that olfactory CNG channels target to lipid rafts and that disruption of lipid raft microdomains dramatically alters the function of CNGA2 channels. 展开 关键词: Ion Channels Membrane Microdomains 离子通道 DOI: 10.1124/mol.65.3.503 被引量: 133 ...
Lipid rafts represent a subcompartment of the plasma membrane that coordinate and regulate varieties of signaling processes while caveolins are the integral membrane protein of the lipid raft. To study the role of lipid raft in ischemic preconditioning (PC) of the heart, rat hearts were perfused ...
Exosomes released from cancer cells are small vesicles originating from the outward budding of lipid rafts that carry various mitogenic proteins that then act locally in an autocrine/paracrine manner to stimulate cancer cell growth. However, exosomes isolated from the culture media of breast cancer ...
Apoptosis of lung epithelial and endothelial cells by exposure to cigarette smoke (CS) severely damages the lung tissue, leading to the pathogenesis of emphysema, but the underlying mechanisms are poorly understood. We have recently established a direct correlation between decreased lipid raft CFTR expr...
Understanding the diversity of membrane lipid composition Nat. Rev. Mol. Cell Biol., 19 (5) (2018), pp. 281-296 CrossrefView in ScopusGoogle Scholar [36] K. Simons, J.L. Sampaio Membrane organization and lipid rafts Cold Spring Harb. Perspect. Biol., 3 (10) (2011), p. a004697 ...