Lipid geometry has been proposed to act in the formation of transport carriers by promoting membrane curvature. However, evidence for this role has come from studies using simplified membranes, while confirmatio
Quantitative investigation of the role of palmitoylation in protein partitioning to raft domains in GPMVs. Article CAS PubMed PubMed Central Google Scholar Gupta, N. & DeFranco, A. L. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte ...
Microscopic, membranous vesicles known as extracellular vesicles (EVs) have been proposed to play a role in the mechanisms underlying central nervous system (CNS) diseases. EVs are secreted by a variety of cells, including myeloid, endothelial, microglial, oligodendroglial, and mesenchymal stem cells...
Diet intervention has been proposed as a powerful tool to prevent the development of the metabolic syndrome, since healthy diets have been shown to have a protective role against the components of the metabolic syndrome. Particularly, dietary fatty acids are capable of modulating the deleterious effec...
Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their role in receptor signaling on the plasma membrane (...
Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin. Cell Dev. Biol. 40, 41–51 (2015). CAS PubMed PubMed Central Google Scholar Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. ...
Interestingly, these mutants were unable to accumulate ROS at the tip of root hair cells and the Ca2+ gradient was absent. However, addition of extracellular ROS rescued the phenotype and favored cell elongation.7 Evidence for the role of ROS in sustaining polarized growth was strengthened by ...
This paper reviews the key role of membrane proteins in the simultaneous regulation of other signal elements (MAPK and ABA signals) and regulatory factors (transcription factors, microRNAs) in metal tolerance mechanisms in plants. Moreover, we also emphasize the role of membrane protein-lipid-ion ...
cells Review The Role of Stem Cells and Their Derived Extracellular Vesicles in Restoring Female and Male Fertility Ahmad Yar Qamar 1,2 , Tariq Hussain 2, Muhammad Kamran Rafique 2, Seonggyu Bang 1, Bereket Molla Tanga 1,3, Gyeonghwan Seong 1, Xun Fang 1, Islam M. Saadeldin 1 and ...
review, we identified the metabolism of sphingolipids, sphingolipids' role in cell signal transduction cascades, and viral infection mechanisms. Also, we outlined ASMase structure and underlying mechanisms inhibiting viral entry 40 with the aid of inhibitors of acid sphingomyelinase (FIASMAs). In ...