Lipid geometry has been proposed to act in the formation of transport carriers by promoting membrane curvature. However, evidence for this role has come from studies using simplified membranes, while confirmation in the more physiologic setting of native membranes has been challenging, as such ...
Microscopic, membranous vesicles known as extracellular vesicles (EVs) have been proposed to play a role in the mechanisms underlying central nervous system (CNS) diseases. EVs are secreted by a variety of cells, including myeloid, endothelial, microglial, oligodendroglial, and mesenchymal stem cells...
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeuti...
Quantitative investigation of the role of palmitoylation in protein partitioning to raft domains in GPMVs. Article CAS PubMed PubMed Central Google Scholar Gupta, N. & DeFranco, A. L. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte ...
Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their role in receptor signaling on the plasma membrane (...
2.Variationsofacommonsorting machineSeverallayersofregulationandtargeting:providespecificityDifferentlipidsphosphoinositides;smallGTPases;GGAs LipidsCholesterol,sphingoipids,phosphoinositidesRafts(lipidmicrodomains)mediateclathrin-independentvesicleformationparticipateinsortingattheTGNratiodiffer:maintaintheparticipationofmembrane...
On the role of carbonic anhydrase in the early phase of fish otolith mineralization The first step in the formation of fish otoliths, calcified structures which are responsible for the internalization of gravitational information, is based... M Beier,R Anken - 《Advances in Space Research》 被引...
Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin. Cell Dev. Biol. 40, 41–51 (2015). CAS PubMed PubMed Central Google Scholar Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. ...
Phosphatidylserine (PtdSer), an essential constituent of eukaryotic membranes, is the most abundant anionic phospholipid in the eukaryotic cell accounting for up to 10% of the total cellular lipid. Much of what is known about PtdSer is the role exofacial PtdSer plays in apoptosis and blood clott...
Here, the authors discuss the biological role of interleukin-2 (IL-2) in the immune system, focusing on recent advances in our understanding of how IL-2 signals have different effects on various T cell populations and how this knowledge can be harnessed