We propose that redistribution of specific membrane microdomains, termed rafts, during cell migration is a pivotal step in achieving polarity. On the one hand, partitioning of molecules into rafts might help to localize proteins at ...
the backbone of sphingomyelins is sphingosine. Bilayers of SM phospholipids react differently to cholesterol, and are more highly compressed yet have decreased permeability to water. SM comprises lipid rafts, stable nanodomains
Keywords Lipid domains Nucleation Spinodal decomposition Domain growth and coarsening Lipid rafts Raft sizes Sorry, something went wrong. Please try again and make sure cookies are enabledReferences [1] O.G. Mouritsen Physics of biological membranes P.M.D. Baeriswyl, M. Droz, A. Malaspinas (Eds...
S-palmitoylation is post-translational modification, which consists in the addition of a C16 acyl chain to cytosolic cysteines and which is unique amongst lipid modifications in that it is reversible. It can thus, like phosphorylation or ubiquitination, act as a switch. While palmitoylation of solu...
Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem. 2009;284:27384–92. CAS PubMed PubMed Central Google Scholar Gault C, Obeid L, Hannun Y. An overview ...
Accordingly, it has been demonstrated that estradiol acts as home- ostatic modulator of lipid rafts, thus preserving lipid balance in neuronal membrane microdomains [94]. The specific impact of estradiol on dopamine metabolism mainly accounts for the reduced vulner- ability ...
Whether or not there are somatic mutations of the IgV genes seems to be hardwired in CLL and seems to predetermine the likelihood that subsequent adverse events will occur. The upregulation of CD38 and its incorporation into lipid rafts may be one of these adverse events. Its function there ...
Persistently positive antiphospholipid antibodies (aPL) in association with thromboses and/or pregnancy morbidity is the hallmark of the antiphospholipid syndrome (APS). The management of aPL-positive patients has been focused on utilizing traditional an
Briefly describe one experimental method or tool used currently to study lipid rafts. Explain the purpose of immunologic tests: HIV tests. How to find the most precise measurement when using an instrument for measuring. Explain with the help of an example. How does a pedometer help people reach...
CLN1 CLN1/Palmitoyl protein thioesterase 1 (PPT1)306 aa, soluble protein Lysosomal matrix, extralysosomal vesicles, lipid rafts, ER and presynaptic areas in neurons Palmitoyl thioesterase; associated to endo/exocytosis in synaptic vesicle recycling, to cholesterol metabolism and to apoptosis CLN2 CLN...