Lipid rafts are specialized membrane microdomains enriched in cholesterol, sphingolipids and caveolin. They are important in the organization of GPCR-protein complexes and the regulation of signaling. Given the emerging significance of lipids with respect to GPCR structure and activation, we have ...
Results show that the addition of cholesterol significantly increased both the amount of insoluble lipid rafts-like structures and their stability, and that the availability of a minimum amount of sphingolipid was necessary to produce larger amounts of more stable structures. However, the addition of...
Lipid rafts, cholesterol, and the brain ZeljkaKorade,Anne K.Kenworthy, inNeuropharmacology, 2008 Abstract Lipid raftsare specializedmembrane microdomainsthat serve as organizing centers for assembly of signaling molecules, influencemembrane fluidityand trafficking ofmembrane proteins, and regulate different cel...
Lipid rafts are sphingolipid- and cholesterol-rich domains of the plasma membrane which contain a variety of signalling and transport proteins. Different s... V Michel,M Bakovic - 《Biology of the Cell》 被引量: 274发表: 2012年 Lipid rafts, protein scaffolds, and neurologic disease Benarroch ...
cholesterol; apoptosis; prostate cancer; Akt; ERK Abstract BACKGROUND Lipid rafts are cholesterol-enriched microdomains in cell membranes that have been shown to regulate signal transduction. We investigated whether membrane cholesterol could regulate apoptosis and attempted to elucidate the mechanism by whi...
Cholesterol in lipid rafts regulates Akt pathway activation and determines cell survival in LNCaP prostate cancer xenograftsdoi:10.1016/S1569-9056(03)90411-8Liyan Zhuang and Jayoung Kim and Fanglei You and Rosalyn M Adam and Keith R Solomon and Michael R Freeman...
Rafts, cholesterol- and sphingolipid-rich membrane microdomains, have been shown to play an important role in immune cell activation. More recently rafts were implicated in the signal transduction by members of the TNF receptor (TNFR) family. In this study, we provide evidences that the raft micr...
However, few reports have described the relationship between lipid rafts and porcine rotavirus (PRV) infection. In this study, we investigated whether or not the locally high concentrations (3–5 fold) of cholesterol present in lipid rafts are required for PRV infection, and further examined which...
(lipid rafts) at the immunological synapse, while also exposing phosphatidylserine (PS) within the synapse, thus creating a negatively charged sink that sequesters and inactivates any residual perforin. The resistance of CTLs to perforin underpins their capacity to kill multiple targets, and enables ...
Lipid rafts are major structural components in plasma membranes that play critical roles in many biological processes including virus infection. However, few reports have described the relationship between lipid rafts and porcine rotavirus (PRV) infectio