Next, we propose a potential mechanism for regulating lipid rafts in the brain via local control of cholesterol biosynthesis by neurotrophins and their receptors. Finally, we discuss evidence that altered cholesterol metabolism and/or lipid rafts play a critical role in the pathophysiology of multiple...
Lipid rafts, cholesterol, and the brain Abstract Lipid raftsare specializedmembrane microdomainsthat serve as organizing centers for assembly of signaling molecules, influencemembrane fluidityand trafficking ofmembrane proteins, and regulate different cellular processes such asneurotransmissionandreceptor trafficking...
Results show that the addition of cholesterol significantly increased both the amount of insoluble lipid rafts-like structures and their stability, and that the availability of a minimum amount of sphingolipid was necessary to produce larger amounts of more stable structures. However, the addition of...
Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly extracted from the lipid bilayer by biomembranes, which jeopardizes membrane stability and results ...
cholesterol; apoptosis; prostate cancer; Akt; ERK Abstract BACKGROUND Lipid rafts are cholesterol-enriched microdomains in cell membranes that have been shown to regulate signal transduction. We investigated whether membrane cholesterol could regulate apoptosis and attempted to elucidate the mechanism by whi...
Role of cholesterol in the formation and nature of lipid rafts in planar and spherical model membranes. Biophys. J. 86, 2965–2979 (2004). Article CAS PubMed PubMed Central Google Scholar Momin, N. et al. Designing lipids for selective partitioning into liquid ordered membrane domains. Soft...
Cholesterol and its derivatives Lipoproteins Biological functions of lipids References & Edit HistoryQuick Facts & Related Topics Images & Videos For Students lipid summary Related Questions Why are lipids important? What are lipid rafts? Discover ...
lipid rafts, or cholesterol- and glycosphingolipid- enriched microdomains, in the cell membrane a possible sited for the organization of spatially defined signals. For example, to stimulate axon elongation, cell adhesion molecules require functional rafts in the growth cone periphery. An extracellular...
Cholesterol in lipid rafts regulates Akt pathway activation and determines cell survival in LNCaP prostate cancer xenograftsdoi:10.1016/S1569-9056(03)90411-8Liyan Zhuang and Jayoung Kim and Fanglei You and Rosalyn M Adam and Keith R Solomon and Michael R Freeman...
Naim, D. Steinhagen, Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle, Veterinary Microbiol. 179 (2015) 204e212.BROGDEN G. Cholesterol - rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle [ J ]. Vet Micm...