Lipid rafts, cholesterol, and the brain ZeljkaKorade,Anne K.Kenworthy, inNeuropharmacology, 2008 Abstract Lipid raftsare specializedmembrane microdomainsthat serve as organizing centers for assembly of signaling molecules, influencemembrane fluidityand trafficking ofmembrane proteins, and regulate different cel...
These results show that sphingolipids and cholesterol are major constituents of rafts also in the human brain and that the main brain gangliosides are distributed in rafts to a similar degree. Moreover, lipid rafts might be considered in the pathology of Alzheimer's disease....
Lipid rafts, cholesterol, and the brain Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and tra... Z Korade,AK Kenworthy - 《Neuropharmacology》 被引量: 332发表: 2008年 Lipid rafts in health and dis...
Fantini J, Barrantes FJ (2009) Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function. Biochim Biophys Acta 1788:2345–2361 PubMed CAS Google Scholar Pandit SA, Jakobsson E, Scott HL (2004) Simulation of the early stages of nano-domain formation in mixed bilayers...
One solution is to embed subunits into a part of the plasma membrane that is not fluid and can hold moving parts close—lipid rafts. These considerations apply not only to cofactors, but also to inhibitors; positioning a sensor in lipid rafts ensures their close proximity to an inhibitor, ...
structures including, among others, higher levels of sphingolipids, particularly ceramides, cholesterol, and oleic acid in myelin membranes of oligodendrocyte cells compared to other brain components, neutral lipid deposits in astrocytes, and particular lipid class and fatty acid profiles of synaptic ...
Results show that the addition of cholesterol significantly increased both the amount of insoluble lipid rafts-like structures and their stability, and that the availability of a minimum amount of sphingolipid was necessary to produce larger amounts of more stable structures. However, the addition of...
is greatly influenced by nutrients, particularly sugars and FAs [103]. Triglycerides account for 90.0% of all dietary lipids (TG). Phospholipids are also present in cholesterol and cholesterol esters in the diet, in addition to triglycerides [104]. The lingual lipase enzyme and gastric lipase ...
Myelin in cross section is a spiral structure constituted by multiple layers of a spe- cialized extension of the oligodendrocyte plasma mem- brane that wraps around axons (reviewed in [24]). The composition of myelin is characterized by high proportions of cholesterol and glycosphingolipids, ...
Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly extracted from the lipid bilayer by biomembranes, which jeopardizes membrane stability and results ...