Lipid rafts, cholesterol, and the brain Abstract Lipid raftsare specializedmembrane microdomainsthat serve as organizing centers for assembly of signaling molecules, influencemembrane fluidityand trafficking ofmembrane proteins, and regulate different cellular processes such asneurotransmissionandreceptor trafficking...
However, lipid accumulation production of lipotoxic metabolites induced by impaired lipid metabolism in the brain may further trigger central nervous system diseases and injuries. LDs are independent organelles associated with lipid storage, for example, excess free cholesterol (FC) is converted to ...
Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly extracted from the lipid bilayer by biomembranes, which jeopardizes membrane stability and results ...
Brain lipid is composed of cholesterol and phosphoglycerides that are rich in the preformed fatty acids, primarily arachidonic and docosahexaenoic (DHA), and not the parent EFAs. From:Handbook of Biological Physics,1995 Also in subject areas: ...
structures including, among others, higher levels of sphingolipids, particularly ceramides, cholesterol, and oleic acid in myelin membranes of oligodendrocyte cells compared to other brain components, neutral lipid deposits in astrocytes, and particular lipid class and fatty acid profiles of synaptic ...
cholesterol; apoptosis; prostate cancer; Akt; ERK Abstract BACKGROUND Lipid rafts are cholesterol-enriched microdomains in cell membranes that have been shown to regulate signal transduction. We investigated whether membrane cholesterol could regulate apoptosis and attempted to elucidate the mechanism by whi...
Myelin in cross section is a spiral structure constituted by multiple layers of a spe- cialized extension of the oligodendrocyte plasma mem- brane that wraps around axons (reviewed in [24]). The composition of myelin is characterized by high proportions of cholesterol and glycosphingolipids, ...
One solution is to embed subunits into a part of the plasma membrane that is not fluid and can hold moving parts close—lipid rafts. These considerations apply not only to cofactors, but also to inhibitors; positioning a sensor in lipid rafts ensures their close proximity to an inhibitor, ...
Cholesterol and its derivatives Lipoproteins Biological functions of lipids References & Edit HistoryQuick Facts & Related Topics Images & Videos For Students lipid summary Related Questions Why are lipids important? What are lipid rafts? Discover ...
One key tenet of the raft hypothesis is that the formation of glycosphingolipid- and cholesterol-rich lipid domains can be driven solely by characteristic lipid-lipid interactions, suggesting that rafts ought to form in model membranes composed of appropriate lipids. In fact, domains with raft-li...