Department of General SurgeryYi LIUWei-juan XUQing-hua XIA华中科技大学学报(医学英德文版)PENG W,LIU Y,XU W J,et al.Role of Beclin1-dependent autophagy in cardioprotection of ischemic preconditioning[J].J Huazhong Univ Sci Technol Med Sci,2013,33(1):51-56.Role of Beclin 1-dependent ...
Interestingly, c-FLIPLÀ / À T cells generate more active caspase 8 (p18) than wild-type T cells, indicating that the apoptotic and antinecrotic activities of caspase 8 may be independent. In addition, c-FLIPLÀ / À T cells display increased induction of autophagy, which promotes T...
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeos
introduce the function of Beclin 1 interactome in autophagy and phagocytosis, review the recent evidence indicating that Beclin 1 regulates autophagy and APP processing in AD, and finally examine the potential mechanisms through which Beclin 1 dysfunction could be involved in the pathogenesis of AD. ...
Stimulation of Autophagy 自噬可以是基线/结构性的,也可以是刺激的。结构性自噬发生在低水平,降解未折叠和受损的蛋白质,因此提供持续的细胞保护和代谢底物的供应。作为对某些刺激的反应,自噬可以被高度激活,导致非特异性或特异性底物的大规模降解。 缺乏营养和氨基酸导致哺乳动物雷帕霉素靶标复合物1(MTOR)从ULK复合物...
Furthermore, induction of autophagy by BEO is beclin-1 independent, occurs in a concentration-dependent manner and is unrelated to the ability of BEO to induce cell death. In order to identify the active constituents responsible for these effects, the two most abundant monoterpenes found in the ...
the autophagy proteins, Beclin1 and LC3B, as well as those of the inflammatory factors, IL-6 and TNF-α, were increased in LPS-induced mouse AECII, and that SIRT1 protected against damage in mice with acute respiratory distress syndrome and in mouse AECII in vitro following LPS treatment....
Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent catabolic pathway involved in the tumorigenesis
Autophagy is a process that describes the degradation and recycling of proteins and intracellular components in response to starvation or stress. At the early stage of tumour development, autophagy functions as a tumour suppressor. Expression of beclin 1 (BECN1), a mammalian orthologue of the yeast...
Autophagy maintains cellular homeostasis during low energy states. According to the current understanding, glucose-depleted cells induce autophagy through AMPK, the primary energy-sensing kinase, to acquire energy for survival. However, contrary to the p