Beclin1与人类疾病如肿瘤、神经系统退行性疾病的关联.最后,简要介绍了实验室常用于Beclin1 研究的工具. 关键词Beclin1;自噬;凋亡;肿瘤;神经系统退行性疾病 中图分类号R34 Beclin1RegulatesApoptosisandAutophagy ZHANGYu-Qing 1) ,ZHANGLi-Hui 1) ,WEIEr-Qing ...
Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 4, 947-948.Wang JR (2008) Beclin1 bridges autophagy, apoptosis and dif- ferentiation. Autophagy 4(7):947-948J. Wang, "Beclin 1 bridges autophagy, apoptosis and differen- tiation," Autophagy, vol. 4, no. 7, pp. 947-...
Beclin1is involved in regulation of apoptosis and autophagy during replication of ectromelia virus in permissive L929cells. Martyniszyn L,Szulc L,Boratyn’’ska A,et al. Archivum Immunologiae et Therapiae Experimentalis . 2011Lech Martyniszyn,Lidia Szulc,Anna Boratynska.Beclin 1 is Involved in...
BECN1(beclin 1) encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multipl...
[关键词]Beclin1; 过表达; 自噬; 黑色素瘤; 上皮间质转化 Overexpression of Beclin1 enhances autophagy and inhibits epithelial mesenchymal transition in melanoma A375 cells HAN Zhao1, GAO Yanling2, ZHANG Jianzhong1, ZHANG Ling...
BECN1(beclin 1) encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multipl...
All Beclin 1/BECN1 genes Beclin 1/BECN1 基因功能 This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This ...
Alzheimer’s disease (AD) is characterized by accumulation of senile amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles causing progressive loss of synapse and neuronal death. Out of the various neuron death modalities, autophagy and apoptosis
2. Beclin 1: a critical autophagy regulator in the heart 3. Regulation of Beclin 1 by post-translational modifications 4. Cross-talk between apoptosis and autophagy via Beclin 1-mediated signaling 5. Targeting Beclin 1-mediated autophagy regulation as a therapeutic strategy for heart diseases 6. ...
We found that the autophagic flux was greater in CSC-enriched breast tumor cells than in non-CSC-enriched adherent ones, which correlated with high Beclin 1 expression in mammospheres. We also found that the maintenance and tumorigenicity of breast CSCs is dependent on Beclin 1 and autophagy. ...