The role of BDNF in depression on the basis of its location in the neural circuitry. H Yu,Z y Chen. Acta Pharmacological Sinica . 2011Yu H, Chen ZY (2011) The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin 32: 3-11.Yu H, ...
Here, we present an overview of the current knowledge concerning BDNF actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (NAc) and amygdala as their rela- tion to depression. Keywords: BDNF; depression; antidepressant; neural circuitry Acta Pharmacologica ...
role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of ...
For instance, while subthreshold depression and depressive symptoms are more common in later life (Beekman et al, 1995), they are often misattributed to aging per se, leading to underdiagnosis of depression. Animal studies show that the effects of stress on cognitive, neuroendocrine, biochemical,...
However, the BDNF r... I Wens,C Keytsman,N Deckx,... - 《European Journal of Neurology》 被引量: 15发表: 2016年 Brain-derived neurotrophic in mania, depression, and euthymia in bipolar disorders: a systematic review and meta-analysis Objective: In bipolar disorder (BD), brain-derived ...
In addition, stress is reported to decrease levels of BDNF in these cell layers. Thus, atrophy or death of these neurons as a result of prior neuronal insult or genetic vulnerability could contribute to the pathophysiology of depression, and could explain why stress leads to depression only in ...
BDNF disruption in both rodents and humans is associated with neurobehavioral alterations and psychiatric disorders. A unique feature of Bdnf transcription is regulation by nine individual promoters, which drive expression of variants that encode an identical protein. It is hypothesized that this unique ...
[17] Guilloux J.P., Douillard-Guilloux G., Kota R., Wang X., Gardier A.M., Martinowich K., et al., Molecular evidence for BDNF- and GABArelated dysfunctions in the amygdala of female subjects with major depression, Mol. Psychiatr., 2012, 17, 1130–1142 http://dx.doi.org/10.1038...
The metabolic deficits displayed by TrkB.T1 mutant mice suggest a novel role of BDNF in β-cell function. To further dissect this phenotype, we studied insulin secretion in isolated islets in response to different stimuli. WT islets were cultured overnight in 5.5 mM glucose. The next day,...
Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has attracted significant attention of scientists. BDNF is involved in the pathophysiology of many psychiatric disorders associated with suicidal behavior including depression, post-...