Evidence suggests that the Val66Met variant of the brain-derived neurotrophic factor (BDNF) gene may play a role in the etiology of Obsessive-Compulsive Disorder (OCD). In this study, the role of the BDNF Val66Met variant in the etiology and the phenotypic expression of OCD is investigated....
Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior ...
Neurotrophins are a family of proteins that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: NGF, BDNF, NT-3 and NT-4. Among them, BDNF is mostly studied in the taste system due to its high expressio...
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as...
BDNFAbuse of alcohol triggers neurodegeneration in human brain. Minocycline has characteristics conferring neuroprotection. Current study evaluates the role of the CREB-BDNF signaling pathway in mediating minocycline's neuroprotective effects against alcohol-induced neurodegeneration. Seventy adult male rats ...
the role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of ...
http://dx.doi.org/10.1016/j.neuroscience.2012.11.022 253 the available literature, the case for a direct role for BDNF in thyroid-mediated e?ects in the brain is not compelling. We conclude that delineation of the potential role of neurotrophins in TH-mediated neuronal development may be ...
BDNF, a small secreted protein, and its receptor, NTRK2 (also known as TRKB), have important roles in neuronal development, differentiation, maintenance, and plasticity throughout life. In the brain, two isoforms of NTRK2 are abundantly expressed: full-length (NTRK2-FL) and trun- cated ...
Diagnostic and statistical manual of mental disorders BDNF: Brain derived neurotrophic factor TNF-a: Tumor necrosis factor-alpha IL: Interleukin GnRH: Gonadotrophin releasing hormone FTM: Female to male MTF: Male to female References Skordis N, Kyriakou A, Dror S, Mushailov A, Nicolaid...
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006; 311: 864–868. 34 Yu T, Guo M, Garza J, Rendon S, Sun XL, Zhang W et al. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of ...