our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF ...
Neurotrophins such as brain-derived neurotrophic factor (BDNF) play an important role in the proliferation and survival of cholinergic, dopaminergic, and serotonergic neurons. With high BDNF gene expression in the hippocampus and prefrontal cortex, BDNF is a regulatory factor for building and ...
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as...
Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior ...
Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein marker of inhibitory interneurons. Recent studies have identified the key functions of SST in modulating cortical ...
Brain-derived neurotrophic factor (BDNF) is an important signaling molecule that participates in the regulation of neurogenesis, as well as neuronal growth and survival in the central nervous system. In this review we discuss its molecular structure, the regulation of gene and protein expression, the...
the role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of ...
The Role of Specific Brain-Derived Neurotrophic Factor (BDNF) Promoters in Obesitydoi:10.1109/TCOMM.2007.900619interference mitigationsignal acquisitiontiming synchronizationultra-wideband (UWBIt is known that a major practical implementation challenge of ultra-wideband (UWB) receivers is the design of the...
Neurotrophins are a family of proteins that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: NGF, BDNF, NT-3 and NT-4. Among them, BDNF is mostly studied in the taste system due to its high expressio...
(PD) and the G196A polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been investigated in several case-control studies, producing contradictory results: one study indicated that homozygocity of AA is associated with PD, another study produced the oppo- site result, whereas ...