Also, the BDNF Val66Met polymorphism affects episodic memory and affective behaviors, and results in a defect in regulated release of BDNF. Methods: Given the purported role of hippocampal synaptic plasticity in memory, we examined synaptic neurotransmission and plasticity in the hippocampal CA3-CA1 ...
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as...
Here, we present an overview of the current knowledge concerning BDNF actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (NAc) and amygdala as their rela- tion to depression. Keywords: BDNF; depression; antidepressant; neural circuitry Acta Pharmacologica ...
DHA has been shown to induce expression of BDNF, a vital mediator of synaptic transmission and biomarker of neurologic disorders, via the p38 mitogen-associated protein kinase (MAPK) pathway (Sun et al., 2018). In infants, DHA plays a critical role in ensuring optimal visual and cognitive gro...
The Role of Specific Brain-Derived Neurotrophic Factor (BDNF) Promoters in Obesitydoi:10.1109/TCOMM.2007.900619interference mitigationsignal acquisitiontiming synchronizationultra-wideband (UWBIt is known that a major practical implementation challenge of ultra-wideband (UWB) receivers is the design of the...
Neurotrophins such as brain-derived neurotrophic factor (BDNF) play an important role in the proliferation and survival of cholinergic, dopaminergic, and serotonergic neurons. With high BDNF gene expression in the hippocampus and prefrontal cortex, BDNF is a regulatory factor for building and ...
Meanwhile, the role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. ...
(2007), 89 THE ROLE OF BDNF IN MICROGLIA-NEURON SIGNALLING AFTER PERIPHERAL NERVE INJURY. European Journal of Pain, 11: S36–S37. doi: 10.1016/j.ejpain.2007.03.103 Author Information University of Toronto, Centre for the Study of Pain, and Program in Neurosciences and Mental Health, ...
Brain-derived neurotrophic factor (BDNF) is an important signaling molecule that participates in the regulation of neurogenesis, as well as neuronal growth and survival in the central nervous system. In this review we discuss its molecular structure, the regulation of gene and protein expression, the...
(Supplementary Fig.5). Since it has also been reported that deletion of BDNF in the liver does not impair glucose tolerance26, we focused on the skeletal muscle and investigated BDNF expression in this organ. To assure a rigorous immunohistochemistry analysis, particularly in muscle, a tissue ...