This chapter provides an overview of BDNF-TrkB signaling in the pathophysiology of mood disorders and in the mechanistic action of therapeutic agents. The author will propose the use of TrkB agonists and antagonists as novel therapies for mood disorders. It is hoped that the development of ...
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets Depression is the most prevalent and among the most debilitating of psychiatric disorders. The precise neurobiology of this illness is unknown. Several lin... JC Zhang,W Yao,H ...
The 'neurotrophin hypothesis of depression' is based largely on correlations between stress or antidepressant treatment and down- or upregulation, respectively, of brain-derived neurotrophic factor (BDNF). Genetic disruption of the signaling pathways involving BDNF and its receptor, the tyrosine kinase ...
Control of CREB expression in tumors: From molecular mechanisms and signal transduction pathways to therapeutic target GSK3 signaling in neural development Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease 相信关心抗衰老领域的不少小伙伴在去年十二月看过关于“Small molecule cognitive en...
Here, we present an overview of the current knowledge concerning BDNF actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (NAc) and amygdala as their rela- tion to depression. Keywords: BDNF; depression; antidepressant; neural circuitry Acta Pharmacologica ...
2023年5月 基于BDNF信号通路研究蓝光对小鼠抑郁 样行为的调节机制 Exploringthemechanismofbluelightregulationofdepression-like behaviorinmicebasedonBDNFsignalingpathway 二〇二三年五月 分类号:R318.51学校代码:10058 硕士学位论文 (专业型) 全日制 非全日制 作者姓名:***养单位:天津工业大学 专业类别:电子信息领域(方...
[15]Nakajima K, Kohsaka S. Microglia: neuroprotective and neurotrophic cells in the central nervous system[J]. Current Drug Targets-Cardiovascular & Hematological Disorders, 2004, 4:5-84. [16]McCoy M K, Tansey M G. TNF signaling inhibition in the CNS: implications for normal brain function ...
Role of BDNF/ BDNF and sleep slow wave changes indicate ketamine- TrkB signaling in antidepressant-like effects of a group II induced plasticity in major depressive disorder. Int J metabotropic glutamate receptor antagonist in animal Neuropsychopharmacol, 2013, 16(2): 301-11 models of depression. ...
CREB (cAMP-response element binding protein) signaling is implicated in depression pathology and antidepressant responses. However, the role of CREB and associated brain derived neurotrophic factor (BDNF) signaling in rapid and long-lasting antidepressant effects remains unclear. Here, we demonstrated ...
Interestingly, the antidepressant potentials of APN KO mice were abolished by TrkB antagonist K252a, IKK inhibitor Bay11-7082, and AdipoRon suggesting crosstalk between TrkB/BDNF signaling and NFκB in depression. Furthermore, the effects of Bay11-7082 were abolished by a TrkB/BDNF activator (7,...