The gray line represents input DNA control ChIP–seq. c, XY scatterplot of RNAPII travel ratio of all expressed genes from adult (x axis) and old (y axis) liver in total RNAPII ChIP–seq data. Each dot represents a gene. Each gene is the average of n = 3 mice per group. d,...
6A). The same results were observed in GSE207422 patient 05 (pretreatment) versus patient 11 (posttreatment achieving major pathology response [MPR]) (Fig. 4B and Supplementary Fig. 6B). Moreover, after treatment with neoadjuvant immunotherapy combined with chemotherapy, the AUCell of the PPARG ...
7a). Transfection experiments showed classifier 3 induced stronger Huh7 cell death compared to L-02, while classifier 4 was more cytotoxic to L-02 versus Huh7 (Supplementary Fig. 7d and g, h, Supplementary Fig. 8b, c, and h–k). Collectively, these results demonstrated that our PROMITAR...
The differences in reported observations may involve the use of proviruses to express viral components versus transfected DNAs. To date, the precise role of nuclear export in retroviral gRNA translocation to virus particle assembly sites remains poorly understood for HIV-1, let alone HIV-2 and ...
S3l). Thus, this data confirms the ability of eCLIP with input normalization to specifically isolate enrichment between abundant snoRNA classes, and suggests that (at least for the RBPs profiled to date here) we see stronger overlap between rRNA precursor and C/D-box versus H/ACA-box snoRNA...
c The relative mRNA level (6 h.p.f. versus 0.5 h.p.f.) of reporter genes with different structural contexts of Elavl1a binding motif in control and elavl1a morphants, n = 3 for each group, error bars, mean ± s.d.; P values were determined by two-sided Student...
(C) Malignant cells (dots) from EPN and GBM scored for the EPN-Neuronal-Precursor-like (x axis) versus GBM-NPC2 (y axis) programs. Correlation coefficients, given as r values, are shown in the bottom right quadrants. (D) Aggregated log2-transformed gene expression in EPN-Neuronal-Precurso...
Differentially expressed miRNAs induced by Ang II at the indicated time points were selected using the following criteria; (a) reads in at least one sample were above 256 and (b) showed at least a 1.5-fold change between Ang II-treated samples versus untreated. Cluster Analysis of ...
Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression. Methods To identify miRNAs that are differentially expressed in tumors and tumor subtypes, we carried out highly sensitive expression profiling of 735 miRNAs on samples ...
Based on the cross-comparison of the percentage recovery of selected mRNAs by qPCR and DRS total versus poly(A)+ fraction DRS analyses we first selected mRNAs that were more than 1.2-fold upregulated in the total compared to the poly(A)+ fraction. Upregulation is to be expected if ...