Single-stranded RNA virus genomes may be positive-sense (i.e., the same polarity or nucleotide sequence as the mRNA; designated as ssRNA+), negative-sense (opposite polarity; ssRNA−, needs to be transcribed for mRNA), or ambisense (a mixture of the two, with an ssRNA− replication st...
The application also searches RNA motifs such as polyadenylation site or RNA–protein binding motifs as well as DNA motifs such as enhancers as well as user-specified motif combinations (https://bioinfo-wuerz.de/aimodules/; alternative entry pages: https://aimodules.heinzelab.de or https://...
The observation that pol ε could not synthesise past (CGG)n or (CG)n, yet pol δ could, may be explained by their different enzymatic properties. More specifically, the weak strand displacement activity of pol ε relative to pol δ might preclude it from coping with hairpin-forming repeats...
Conclusion The reduction of viremia that is observed after loss of HBeAg was mainly explained by reduced cccDNA load in the liver, whereas the contribution of down-regulation of pgRNA transcription was relatively small. Enhanced transcription of S-RNA does not explain excessive production of HBsAg. ...
This could be explained if RIND-EDSBs are present in the PCR template of one allele and so could lead to a drop out of that allele. Second, histone deacetylase inhibitors have been found to induce γ-H2AX deposition in several cancer types, especially leukemia [74]. This is similar to ...
As explained above,SCintuitis based on the IFS theory, which has been successfully applied to problems that suffers from noisy and imprecise data. IFS theory represents uncertainty with respect to both the degree of membership and non-membership. The uncertainty associated with the tasks of scoring...
If an analogous chromatin contraction occurs at the TRs of the EBV genome, transcriptional upregulation of LMP genes following perturbation of the EBER2-PAX5-mediated control mechanism might be explained by a looser chromatin conformation that facilitates transcription through the region. Consistent with...
This could be explained by the proportion of promoters containing a TATA-box in the background set of sequences, or by the relatively low complexity of TATA-box motifs which makes them hard to discriminate from background, particularly if we take into account the fact that promoter sequences ...
b Single-nuclear RNA-seq UMAP of 223,438 human kidney cells. Each dot represents a cell, with color coding for the cell types: Endo_GC; endothelial cells of glomerular capillary tuft, Endo_peritubular; endothelial cells of peritubular vessels, Endo_Lymphatic, endothelial cells of lymphatic ...
covalently bound topoisomerase 1 complexes inhibit RNA polymerase II (Pol II)-mediated transcription and are degraded in a transcription-dependent manner by the proteasome13,14. These data indicate that DPCs in general might severely block transcription; however, the extent to which DPCs inhibit ...