Thus far, most research has focused on DPC-induced replication stress owing to the resulting genome instability3. However, because of their bulkiness, DPCs also block transcription, as shown in in vitro transcription studies using bacteriophage T7 RNA polymerase11,12. Furthermore, covalently bound t...
Somewhat unexpectedly, however, we observed a comparable transcription rate of nNEsoft and the genuine nNE, an effect explained in the chapter on molecular dynamics simulations. As seen before for the nanoengine, an nNE lacking the chloroalkane linker is virtually inactive (Fig. 2c, column 1)....
As explained above,SCintuitis based on the IFS theory, which has been successfully applied to problems that suffers from noisy and imprecise data. IFS theory represents uncertainty with respect to both the degree of membership and non-membership. The uncertainty associated with the tasks of scoring...
structures. In different REP-rich genomes the repeats are predominantly located between unidirectionally and convergently transcribed ORFs. REPs are predominantly located downstream from coding regions, and many are plausibly transcribed and function as RNA elements. REPs located inside genes have been iden...
(Williams et al.2021) and methods for detection of environmental RNA (eRNA), which might increase spatiotemporal accuracy and discriminate between the presence of living vs. dead organisms (Pochon et al.2017; Cristescu2019; von Ammon et al.2019) as well as encoding other genetic and ...
If an analogous chromatin contraction occurs at the TRs of the EBV genome, transcriptional upregulation of LMP genes following perturbation of the EBER2-PAX5-mediated control mechanism might be explained by a looser chromatin conformation that facilitates transcription through the region. Consistent with...
structures. In different REP-rich genomes the repeats are predominantly located between unidirectionally and convergently transcribed ORFs. REPs are predominantly located downstream from coding regions, and many are plausibly transcribed and function as RNA elements. REPs located inside genes have been ...
On the other hand, this difference could also be explained by the progressive taxonomy in the Eurotiales, certainly when this is compared with the other orders in this class. This might make this comparison less balanced. It needs to be noted that LSU sequences are not commonly used to ...
like sequences in a numerical format. The handcrafted feature extraction needs a significant amount of background knowledge; therefore, rather than using all of these, we only used the one-hot encoding and NCP methods. Both of the encoding methods are explained briefly in the following ...
Protein Synthesis The process of protein synthesis is explained by the central dogma of molecular biology, which states that: DNA RNA Proteins How does the sequence of a strand of DNA correspond to the amino acid sequence of a protein?