The application also searches RNA motifs such as polyadenylation site or RNA–protein binding motifs as well as DNA motifs such as enhancers as well as user-specified motif combinations (https://bioinfo-wuerz.de/aimodules/; alternative entry pages: https://aimodules.heinzelab.de or https://...
Conclusion The reduction of viremia that is observed after loss of HBeAg was mainly explained by reduced cccDNA load in the liver, whereas the contribution of down-regulation of pgRNA transcription was relatively small. Enhanced transcription of S-RNA does not explain excessive production of HBsAg. ...
b Single-nuclear RNA-seq UMAP of 223,438 human kidney cells. Each dot represents a cell, with color coding for the cell types: Endo_GC; endothelial cells of glomerular capillary tuft, Endo_peritubular; endothelial cells of peritubular vessels, Endo_Lymphatic, endothelial cells of lymphatic ...
in which a specific target DNA sequence is amplified and detected with a fluorescent indicator. If a positive control standard curve is used, qPCR can provide estimation of the absolute quantity of the targeted DNA sequence. As a molecular method, qPCR is ...
If an analogous chromatin contraction occurs at the TRs of the EBV genome, transcriptional upregulation of LMP genes following perturbation of the EBER2-PAX5-mediated control mechanism might be explained by a looser chromatin conformation that facilitates transcription through the region. Consistent with...
As explained above,SCintuitis based on the IFS theory, which has been successfully applied to problems that suffers from noisy and imprecise data. IFS theory represents uncertainty with respect to both the degree of membership and non-membership. The uncertainty associated with the tasks of scoring...
The delay in global demethylation as compared to reduced expression of the Dnmt3 genes might well be explained by a long half-life of DNMT3 proteins. Although starting from lower methylation levels, female cells behaved very similarly (Figures 4E, S4C, and S4D). The observations that ...
This could be explained by the proportion of promoters containing a TATA-box in the background set of sequences, or by the relatively low complexity of TATA-box motifs which makes them hard to discriminate from background, particularly if we take into account the fact that promoter sequences ...
covalently bound topoisomerase 1 complexes inhibit RNA polymerase II (Pol II)-mediated transcription and are degraded in a transcription-dependent manner by the proteasome13,14. These data indicate that DPCs in general might severely block transcription; however, the extent to which DPCs inhibit ...
12). The latter parameter was fitted in the case of the Hathaway et al experiments, or fixed in the case of in vivo heterochromatin formation to w(1, 1, 0) = 100 or w(1, 1, 0) = 1, as explained in Supplementary Fig. 4 and Supplementary Table 3. For TF-based heterochromatin ...