[Keywords] Thyroidcancer; Epigenetic; RNA methylation; Review 近年来,甲状腺癌 (THCA)的发病率增加[1],其 发病因素不明,可能与性别[2],遗传因素[3],射线照射 (主要是外放 射)[4]及促甲状腺激素 (TSH)刺激等有关[5],且发病群体呈年轻化 .[6] 因此,有必要阐明 THCA 发生 和进展的分子机制. 事实上,...
doi:10.3389/fgene.2023.1293897RNA methylationDNA methylationCANCER invasivenessRNA modification & restrictionNON-coding RNADNA methyltransferasesShukla, VaibhavTyagi, AshishFrontiers in Genetics
Figure 6. MTDH expression associates with the estimation of m6A RNA methylation in cancer (A–H). The expression of MTDH mRNA significantly correlates with estimated score of m6A RNA methylation within tumor samples from BLCA, BRCA, CHOL, LUAD, HNSC, KIRC, KIRP, and LIHC (all p < 0.05)....
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation ...
m6A RNA methylation regulators can contribute to malignant progression and impact the prognosis of bladder cancer. Biosci. Rep. 39, BSR20192892 (2019). Article CAS PubMed PubMed Central Google Scholar Liu, Q. et al. Molecular characterization and clinical relevance of N6-methyladenosine regulators...
Previous studies have shown that RNA methylation modification, specifically m1A, is closely associated with cancer-related processes such as proliferation, apoptosis, metabolism, and cell cycle regulation. For example, it contributes to tumorigenesis by perturbing the stability of relevant RNA molecules ...
[12] Culig Z, Hobisch A, Cronauer MV, et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994;54:5474-8. [13] Gregory CW, Johnson RT Jr, Presnell SC, et al. Androgen ...
The Individualized Therapy for Relapsed Malignancies in Childhood (INFORM) consortium4 studied 57 patients with WES, low-coverage whole-genome sequencing, RNA-Seq, methylation, and gene expression microarrays and reported a 50% rate of actionable findings that included overexpression of druggable oncogene...
[4]. Sun, T., Y. Xu, Y. Xiang, et al. Crosstalk between RNA m(6)A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells. Nat Genet, 2023, 55(8): 1324-1335. [5]. Deng, S., J. Zhang, J. Su, et al. RNA m(6)...
Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3. Here, using an unbiased genome-scale CRISPR knockout screen in mouse embryonic stem cells, we identify m6A RNA methylation as a way to restrict ERVs. Methylation of ERV mRNAs is ...