文章主要发现肿瘤细胞上皮间质化(EMT)过程中mRNA的m6A显著上调,其可通过促进EMT关键转录因子Snail的翻译从而促进肿瘤EMT及侵袭转移。文中图片及数据均来源于Lin X, Chai G, Wu Y, et al. RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun...
RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat. Commun. 10, 2065 (2019). Article PubMed PubMed Central CAS Google Scholar Ma, J. et al. METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6-...
m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 18, 2622–2634 (2017). CAS PubMed PubMed Central Google Scholar Vu, L. P. et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic ...
N6-methyladenosine (m6A) methylation is a kind of epigenetic modifications of RNA [26], it can adjust the RNA transcription, editing, translation and stability [27]. The distribution of m6A is found across more than 7000 mRNA and multiple non-coding RNA (ncRNA) transcripts in human cells [28...
N6-methyladenosine (m6A) methylation, which is modified by the METTL3/METTL14 complex, is a dominant internal modification in mammalian RNA and tightly linked to cancer progression. Here we reveal that METTL3-promoted cell migration, invasion, and epithelial-to-mesenchymal transition (EMT) are ...
5.通用的阳性对照和阴性对照适用于任何五中的m6A检测 6.条形的微孔板使得反应可以灵活处理,既可以手动操作,也可以高通量处理 7.简单,可靠和稳定的检测条件 ·产品说明书 Product Overview TheEpiQuik™ m6A RNA Methylation Quantification Kit (Colorimetric)is a complete set of optimized buffers and reagents to...
RNA甲基化是表观遗传学的重要内容之一,其中m6A是较为常见的一种修饰方式,在转录后调控中发挥作用,包括调控基因表达、剪接、RNA编辑、RNA稳定性、控制mRNA寿命和降解、介导环状RNA翻译[1]等方面,因此,RNA甲基化修饰的相关研究已成为当前生命科学领域最热门的方向之一。
RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of snail. Nat Commun. 2019;10:2065. 107. Zuo X, Chen Z, Gao W, Zhang Y, Wang J, Wang J, Cao M, Cai J, Wu J, Wang X. M6A-mediated upregulation of LINC00958 increases lipogenesis and ...
Article:CircSSR1 regulates pyroptosis of pulmonary artery smooth muscle cells through parental protein SSR1 mediating endoplasmic reticulum stress. Periodicals:Respiratory Research IF:4.700 Article:IGF2BP2-m6A-circMMP9 axis recruits ETS1 to promote TRIM59 transcription in laryngeal squamous cell carcinoma...
Luo S et al (2023) METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling. Cell Rep 42(3):112259 Article PubMed CAS Google Scholar Shen H et al (2023) N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6...