Mechanistically, there are two distinct enzymatic routes to generate 2',3'-cyclic phosphate ends - transesterification and cyclization using ATP. In this work, I have investigated reaction pathways that generate and utilize these cyclic phosphate ends in the context of RNA damage and repair. ...
分子生物学基础-RNA的生物合成和损伤修复 第四章 DNA损伤修复 DNADamageRepair 1 目录 一、突变 概念：在某些特殊情况下，基因DNA的碱基顺序发生改变 意义：进化、分化的分子基础；致死性；某些疾病的发病基础；表现型无改变 2 目录 二、遗传信息的突变来源 DNA复制产生误差化学或物理损伤转座子（transposons）的转座...
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MiR-7 is considered to be an important regulator of epithelial cell damage and repair. As the largest epithelium of the human body, the intestinal mucosa epithelium is the link between the human body and the outside world, and plays an important role in the homeostasis of the internal environ...
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Article:LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer Periodicals:Cell Death & Disease IF:8.469 Article:LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngealcarcinoma ...
DksA-RNA polymerase interactions support new origin formation and DNA repair in Escherichia coli. Mol Microbiol, 2019, 111(5): 1382-1397 [8] Van Der Weegen Y, Golan-Berman H, Mevissen T E T, et al. The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled ...
Article:LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer Periodicals:Cell Death & Disease IF:8.469 Article:LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma ...