2005. Rifamycin-mode of action, resistance, and biosynthesis. Chem. Rev. 105:621-632.Floss, H. G. & Yu, T. W. Rifamycin-mode of action, resistance, and biosynthesis. Chem. Rev. 105, 621-632 (2005).Floss H G, Yu T W. Rifamycins mode of action, resistance,and biosynthesis [J]....
Interestingly, both compounds showed different values in terms of potency against replicating and intracellular bacteria suggesting a complex mode of action for these compounds, in fact CFM showed an MIC of 1.209 μg/mL while TBI-166 was inactive (MIC > 25 μg/mL)....
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. 性质 assay ≥97% (HPLC) form powder color orange-brown to red-brown solubility H2O: 1.3 mg/mL (pH 4.3) DMSO: 100 mg/mL H2O: 2.5 mg/mL at 25 °C (pH 7.3) storage temp. −...
Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev 2005; 105:621-632. 2 White RJ, Martinelli E, Gallo GG, Lancini G, Beynon P. Rifa- mycin biosynthesis studied with 13C enriched precursors and carbon magnetic resonance. Nature 1973; 243:273-277. 3 Lal R, Khanna M, Kaur...
as rifampin, rifabutin, rifapentine, and rifaximin have been used for decades in the clinic for the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections2, and their recognized pharmacological mode-of-action is the specific inhibition of prokaryotic DNA-dependent RNA synthesis2,...
To further investigate the structure of the Rox-inactivated rifamycin products, we performed HR-ESI-MS/MS experiments in the negative ion mode, which revealed the presence of a number of significant fragments, as previously reported (Vekey et al., 1989). One of the most abundant fragments for...
Rifamycin¿Mode of Action, Resistance, and Biosynthesis, ArtículoChem Rev. 2005 Feb;105(2):621-32. Research Support, U.S. Gov't, P.H.S.; Reviewdoi:10.1021/cr030112jFloss, Heinz G.Yu, Tin-WeinChemical ReviewsFloss H, Yu T. 2005. Rifamycin; mode of action, resistance, and ...
Summary This chapter contains sections titled: Discovery of the Pioneer Drug Clinically Used Rifamycins Mode of Action of Rifamycins and Structural Requirements for Activity Modulation of Chemotherapeutic Properties Profiles of Rifamycins Targeted at Tuberculosis Treatment Rifampicin (INN), Rifampin (USAN) ...
The multi-functional antibiotic nature of CBR-2092 is substantiated herein through studies that encompass biochemistry, microbiologyAS LYNCHa.Lynch, A. S., E. J. Bonventre, T. B. Doyle, Q. Du, L. Duncan, G. T. Robert- son, and E. D. Roche. 2007. In vitro mode-of-action studi...
Initiation, but not elongation, of RNA synthesis was inhibited by these derivatives. Studies on the mode of action of these inhibitors on B enzyme activity have shown that inhibition took place at two steps of the preinitiation process: both the primary binding of enzyme to DNA and a ...