(1972) Mechanism of action of a rifamycin dervative (AF/013) which is active on the nucleic acid polymerases insensitive to rifampicin. Biochim. Biophys. Acta 49: pp. 1263Riva, S., Fietta, A.,and Silvestri, L. G., 1972, Mechanism of action of a rifamycin derivative (AF/013) which ...
Rifampin is rapidly eliminated in the bile and undergoes progressive enterohepatic circulation to form its primary metabolite, 25-desacetyl rifampin,10 which retains about 20% of rifampicin’s antimicrobial activity.6 It is suggested that arylacetamide deacetylase is the liver esterase involved in the ...
Rifampin The metabolism of Metronidazole can be increased when combined with Rifampicin. Rilonacept The metabolism of Metronidazole can be increased when combined with Rilonacept. Rilpivirine The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Rilpivirine. Riluzole ...
monooxygenase enzyme mechanism of action Sorry, something went wrong. Please try again and make sure cookies are enabledReferences Abdelwahab et al., 2016 H. Abdelwahab, J.S. Martin Del Campo, Y. Dai, C. Adly, S. El-Sohaimy, P. Sobrado Mechanism of rifampicin inactivation in Nocardia far...
ofE. coliand has been implicated inE. coliresistance to numerous antibiotics including ampicillin, rifampicin, and chloramphenicol19. Thus, in addition to the physical barrier imposed by the Gram-negative OM, the ability of auranofin to gain entry into Gram-negative bacteria to exhibit its ...
Pyrazinamide is available as a pure tablet in strengths of 150, 400, or 500mg under multiple trade names and also as a part of fixed drug combinations with rifampicin and isoniazid. Its mechanism of action of is still disputed, but pyrazinamide has a sterilizing action and treatment-...
Tuberculosis (TB), caused by infection withMycobacterium tuberculosis(Mtb), is one of the leading causes of death and poverty worldwide. The rise of multi-drug resistant (MDR), rifampicin resistant (RR), and extensively drug-resistant (XDR) TB poses major challenges in the treatment and eradica...
It is important to note that potent CYP3A4 inhibitors such as ketoconazole and clarithromycin, as well as inducers like rifampicin, can significantly affect the exposure to abemaciclib and its active metabolites. Inhibitors of CYP3A4 can increase plasma levels of abemaciclib, leading to a risk of...
As raltegravir is mostly metabolized by UGT1A1, it should be used with caution when co-administered with strong inducers of UGT1A1, such as rifampicin. This antibiotic has been shown to reduce plasma concentrations of raltegravir, although its impact on the efficacy of raltegravir is unknown. A...
Chemotherapeutic potential of alginate-chitosan microspheres as anti-tubercular drug carriers METHODS: Alginate-chitosan microspheres encapsulating three frontline anti-tuberculous drugs (ATDs), rifampicin, isoniazid and pyrazinamide, were formulated. A ... P Rajesh,GK Khuller - 《J Antimicrob Chemother》...