In this chapter, the work carried out in several laboratories with the aim of elucidating the mode of action of rifampicin on poxviruses is discussed and evaluated, and the effectiveness of other derivatives compared to that of rifampicin. Before discussing the antiviral properties of rifamycins, ...
Pavlov EP, Tushov EG, Kotlyarov LM (1974) The action of rifampicin on the extra-and intracellularly located myco. tuberculosis. Probl Tuberk 52 issue 12: 64–67 CAS Google Scholar Pawlowska I, Pniewski T (1975) Studies on rifampicin (RMP) metabolism in patients with pulmonary tuberculosis....
This suggests that F1082 may have a different mechanism of action compared to current TB drugs. It has been shown to have no antagonistic effect with the first-line anti-TB drugs and it has been shown to synergize with rifampicin by reducing the MIC of ...
in particular those arising from the emergence of multidrug-resistant pathogenic bacteria. This has prompted significant efforts in the development of new small molecule antibiotics1,2,3,4, resulting in a resurgence of interest in natural product research to discover selective, novel mode-of-action t...
Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of mortality and morbidity across the world. Indiscriminate use of
Then statistical processing by principal components analysis was carried out upon those vectors, two conclusions could be drawn: (1) the antibacterial mode of action of Radix Tinosporae is similar to that of rifampicin and norfloxacin, which act on nucleic acid; (2) its active components playing...
• Mode of action: rifampicine binds to the RNA-polymerase* 1) Mutation in KatG:* Ser315 -> Thr* High level of resistance* Found in >50% of INH-R strainsJ Biol Chem
Biochemical studies were also conducted with purified enzymes to obtain further insights into the mode of action of GE23077. Interestingly, the compound displays a behaviour similar to that of rifampicin, an antibiotic structurally unrelated to GE23077: both compounds act at the level of ...
Pretomanid treatments generated a unique distinctive metabolite profile when compared to ampicillin, ethambutol, ethionamide, isoniazid, kanamycin, linezolid, rifampicin and streptomycin. Metabolites which differed significantly only with pretomanid treatment were identified and mapped on to bacterial metabolic...
The MIC values of diospyrin (8.0μg/ml), isodiospyrin (10.0μg/ml), 7-methyljuglone (0.5μg/ml) and neodiospyrin (10.0μg/ml) compared well to those of the known antimycobacterial drugs, ethambutol, isoniazid and rifampicin. A hypothesis on the structure-activity relationship for the ...