(1972) Mechanism of action of a rifamycin dervative (AF/013) which is active on the nucleic acid polymerases insensitive to rifampicin. Biochim. Biophys. Acta 49: pp. 1263Riva, S., Fietta, A.,and Silvestri, L. G., 1972, Mechanism of action of a rifamycin derivative (AF/013) which ...
The result is an antibiotic that no longer adopts the basket-like structure essential for binding to the RNA exit tunnel of the target RpoB, thereby providing the molecular logic of resistance. This unique mechanism of enzymatic inactivation underpins the broad spectrum of rifamycin resistance ...
The mechanism of action of rifamycins as inhibitorsof viral replication appears to differ from that for their bactericidalaction. Their net effect is to inhibit the formation of thevirus particle, apparently by preventing a specific polypeptideconversion.77 Rifamycins bind to the β subunit of ...
all three Kangs exhibit improved activity compared to Rif against RNAP variants carrying common mutations found in RifRMtbclinical isolates. We speculated that the activity of the Kangs against RifRmutants and their potentially novel mechanism of inhibition could...
To elucidate the catalytic mechanism for this atypical ester-to-ether transformation, the crystal structures of substrate-free Rif16 (PDB ID code: 5YSM, Fig.4a) and R-L-bound Rif16 (PDB ID code: 5YSW, Fig.4b) were solved at 1.90 Å and 2.60 Å resolution, respectively. In...
Mechanism of action of antimycobacterial activity of the new benzoxazinorifamycin KRM-1648. The mechanism of antimicrobial activity of KRM-1648 (KRM), a new rifamycin derivative with potent antimycobacterial activity, was studied. Both KRM and rif... Fujii,Saito,Tomioka,... - 《Antimicrobial Agent...
Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many Gram-positive and Gram-negative bacteria by inhibiting RNA polymeras
1. Rifamazine (AF/RP) a dimeric rifamycin, is active against bacterial DNA-dependent RNA polymerase and against viral RNA-dependent DNA polymerase.Anna M.FIETTALaboratori di Microbiologia, Gruppo Lepetit S.p.A., Via Durando 38, 1-20158 Milano, ItalyLuigi G.SILVESTRI...
Wehrli, W., Staehelin, M.: Rifamycins and other ansamycins. In: Antibiotics Vol. 3. Mechanism of action of antimicrobial and antitumor agents. Corcoran, J. W. and Hahn, F. E., (ed). Berlin-Heidelberg-New York: Springer 1975, p. 252...
Al- though the gene encoding GS adenylyltransferase (glnE, AMED_1227) was identified in the chromosome of U32, as is commonly found in streptomycetes [45] and other actinomycetes [46], the mechanism of lacking reversible adenylylation-mediated posttranslational regulation of the GS activity in ...