Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. 性质 assay ≥97% (HPLC) form powder color orange-brown to red-brown solubility H2O: 1.3 mg/mL (pH 4.3) DMSO: 100 mg/mL H2O: 2.5 mg/mL at 25 °C (pH 7.3) storage temp. −20°C ...
• Mode of action: rifampicine binds to the RNA-polymerase* 1) Mutation in KatG:* Ser315 -> Thr* High level of resistance* Found in >50% of INH-R strainsJ Biol Chem
Biochem/physiol Actions: Inhibits the assembly of DNA and protein into mature virus particles. Mode of Action: Inhibits initiation of RNA synthesis by binding to β subunit of RNA polymerase. Properties: assay ………95% (HPLC) form………powder color ………orange-brown to red-brown ...
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. 性质 assay ≥97% (HPLC) form powder color orange-brown to red-brown solubility H2O: 1.3 mg/mL (pH 4.3) DMSO: 100 mg/mL H2O: 2.5 mg/mL at 25 °C (pH 7.3) storage temp. −...
MW 822.94 CAS:13292-46-1 Storage:4℃ Assay………≥97% (HPLC) Form………orange-brown to red-brown powder Solubility……… H2O : 50 mg/mL 说明: Inhibits the assembly of DNA and protein into mature virus particles. Mode of Action: Inhibits initiation of RNA synthesis by binding to β-su...
Mode of action of rifampicins on the RNA polymerase action Biochim. Biophys. Acta (1968) B.K. Bhuyan et al. Differential interaction of nogalomycin with DNA of varying base composition S. Ghosh et al. Chromosomal alterations in the evolution of substrains of Ehrlich-Letrre, mouse ascites ...
We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocidal activity of leucinostatin A and B, alamethicin I and tsushimycin. 展开 关键词: animal models antiprotozoal agents antiprotozoal properties cytotoxicity in vitro mode of action peptide ...
Biochem/physiol Actions Inhibits the assembly of DNA and protein into mature virus particles.Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. 性质 assay ≥97% (HPLC) form powder color orange-brown to red-brown solubility H2O: 1.3 mg/mL (pH 4.3...
Furthermore, the most active compounds 178b-d showed activity to a similar extent against various MDR-Mtb strains, thus revealing a distinct mode of action. Sign in to download hi-res image Fig. 38. Fused 1,2,4-triazoles anti-TB potential. Various triazolopyrimidines 180 (Fig. 38...
Mutations within this region account for up to 95% of the RIF resistance observed [6-8]. INH has a more complex mode of action and resist- ance occurs through several discrete mechanisms involving many genes, therefore detection of INH resistance through molecular tests is less reliable than ...