NAC guides a ribosomal multienzyme complex for nascent protein processing Cotranslational N-terminal methionine excision and acetylation of eukaryotic proteins on ribosomes is coordinated by the nascent polypeptide-associated complex. Alfred M. Lentzsch ...
Ribosomes are important organelles for protein synthesis in living organisms [12]. As fundamental components of ribosomes, RPs are highly conserved during evolution and extensively distributed in tissues [1]. Eukaryotic ribosome (80S) consists of the 60S large and 40S small ribosomal subunits, which...
RIBOSOMAL proteinsALLOSTERIC regulationTRANSFER RNAPEPTIDESRIBOSOMESTo perform an accurate protein synthesis, ribosomes accomplish complex tasks involving the long-range communication between its functional centres such as the peptidyl transfer centre, the tRNA bindings sites and the peptide exit tunnel. How...
protein-protein interactions and increases in the translation rate of p53 mRNA. One of the best documented mechanisms of p53 induction upon nucleolar stress involves the binding of RPs to Mdm2 (mouse double minute 2; also referred to as HDM2 in human)...
halving the copy number of a single RP gene limits the availability of the encoded RP, thereby reducing the number of functional ribosomes that are assembled in the cell and impairing protein synthesis [2]. While this idea is consistent with the available data, there may be other explanations...
Instead, it was Pauling’s long experience as a structural chemist that had emboldened him to infer which type of helical fold would be most compatible with the underlying chemical features of the polypeptide chain. Pauling made scale models of the different parts of the protein molecule, ...
In this work, we showed that the genomic position of the major ribosomal protein locus conditions V. cholerae evolution in the long term. Toward this aim, we experimentally evolved strains in which the S10 locus was either placed at its original position or at the terminal region of the chrom...
Research2MeVt0oaa0lrul7y.mgoeld8, Issue 10, Article R216 Open Access The ribosomal protein genes and Minute loci of Drosophila melanogaster Steven J Marygold*, John Roote†, Gunter Reuter‡, Andrew Lambertsson§, Michael Ashburner†, Gillian H Millburn†, Paul M Harrison¶, Zhan ...
This review article explores the intricate role, and regulation of ribosomal protein in response to stress, particularly emphasizing their pivotal role to
The proline-rich antimicrobial designer peptide Api137 inhibits protein expression in bacteria by binding simultaneously to the ribosomal polypeptide exit tunnel and the release factor (RF), depleting the cellular RF pool and leading to ribosomal arrest at stop codons. This study investigates the addit...