A comprehensive genetic, biochemical, and structural analysis has been made of the contribution of the zinc finger to the function of yeast ribosomal protein YL37a, to date the only study of its kind. Replacement, one at a time, of the cysteines with serines in the motif in YL37a ...
L22b L17e A B E C MT 1 Assembly; exit tunnel L23b L25e A B E C MT 1 L24b L26e A B E C MT 1 X Assembly L25b B CTC-type protein L27b B E C MT X L28b B C MT X L29b L35e A B E C MT 1 X L30b L7e A B E MT X L31b B C L32b B C M L33b...
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(2004) Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol 24: 7654–7668. [18] Jin A, Itahana K, O’Keefe K, Zhang Y (2004) Inhibition of HDM2 and activation of p53 by ribosomal protein ...
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 2012; 441: 1–21. CAS PubMed Google Scholar Plas DR, Thomas G . Tubers and tumors: rapamycin therapy for benign and malignant tumors. Curr Opin Cell Biol 2009; 21: 230–236. CAS ...
revealed that the N-terminal tail of ribosomal protein L27 (RPL27) in bacteria stabilizes tRNA substrates in the PTC, thereby facilitating peptidyl transfer by the ribosome; while ribosomal protein L16 (RPL16) similarly enhances the binding of aminoacyl-tRNA at the A site of the ribosome [33]...
1A). The ribosomal protein L3 (rL3) and several translation factors have a similar but topologically distinct six-stranded β-barrel, “RIFT”5,6 (Supplementary Fig. 1B). The structures of DPBB and RIFT have two-fold pseudo symmetry, indicating they originated as shorter homo-dimeric peptide...
The protein components of ribosomes are interesting from several points of view. First, and most obviously, RPs play critical roles in ribosome assembly and function [7]. Second, several RPs perform important extra-ribosomal functions, including roles in DNA repair, transcriptional regulation and apo...
Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mutant cells. Xrp1 reduces translation and growth, delays development, is responsible for gene expression changes, and causes the cell competition of Rp heterozygous cells from genetic mosaics. Without Xrp1, ...