IL-10 induces growth and differentiation of activated human B cells, whereas PIF induces proliferation of naive B cells. Biological properties of PIF thus appear to be different from those of several other known modul- ators of B cells. This inference is further supported by molecular ...
Blood cells are challenged by intrinsic and exogenous stress that may result in many types of damage to DNA. As a major participant in cell-mediated immunity in blood, T lymphocytes are maintained in their quiescent (resting) state for most of their live
with naive controls, long-term survivors demonstrated immune memory, as evidenced by prolongation of survival when they were rechallenged with tumor cells. ... RP Glick,T Lichtor,H Lin,... - 《Journal of Neurosurgery》 被引量: 15发表: 2006年 Alloantigen-specific prolongation of allograft surv...
Although osteoclasts were not generated in the culture of human peripheral blood mononuclear cells (PBMC) in the presence of RANKL and macrophage colony-stimulating factor (M-CSF), the addition of cyclosporine A (CsA), a potent inhibitor of T-cell function, resulted in the formation of an ...
Induction of systemic lupus erythematosus in naive mice with T-cell lines specific for human anti-DNA antibody SA-1 (16/6 Id+) and for mouse tuberculosis a... Previously we have shown the ability to induce experimental systemic lupus erythematosus (SLE) in naive mice with pathogenic antibodies...
Cell culture and reagents Human peripheral blood of healthy, HIV-negative donors was obtained from the blood bank Heidelberg upon informed consent and according to regulation by the ethics committee of the Medical faculty, Heidelberg University (ethics vote S-024/2022). Resting (naive and memory) ...
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no chemokine has been shown to ha... Michael,D.,Gunn,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 1875发表: 1998年...
Resting B cells suppress tumor im- munity via an MHC class-II dependent mechanism. J. Immunother. 30: 323-332.Watt V, Ronchese F, Ritchie D. ... V Watt,F Ronchese,D Ritchie - 《Journal of Immunotherapy》 被引量: 62发表: 2007年 T helper cell-dependent induction of resting B cell...
Here, using magnetic beads and fluorescence-activated cell sorting, we extensively phenotype the Tck effector cells and conclude that effector function resides within the CD4+CD45RO+, CCR7-, CD49dhigh population, and that these cells are derived from the effector memory CD4+ T cells in resting...
Since the phosphatidylinositol-3 phosphate kinase (PI3K) and Akt (PKB) pathway has been shown in model organisms to regulate both cell size and metabolism, we generated transgenic mice expressing a constitutively active form of Akt (myristoylated Akt, mAkt) in T cells. Naive transgenic T cells ...