Viora, "IFN-𝛼 amplifies human na¨ive B cell TLR-9- mediated activation and Ig production," Journal of Leukocyte Biology, vol. 86, no. 2, pp. 261-271, 2009.Giordani L, Sanchez M, Libri I, Quaranta MG, Mattioli B, Viora M. IFN-α amplifies human naive B cell TLR-9-mediated ...
Among the many signals naive B cells receive, the engagement of the B cell receptor by foreign antigens and cytokines secreted by T cells are critical for B cell activation and differentiation. B cells undergo class switching to achieve a diverse array of effector functions and produce various ...
Deep analysis of B cell activation pathways by our group and others has led to a strong emphasis on the extrafollicular (EF) pathway as a common feature of severe disease14,15,17. Characterized by the induction of T-bet-driven double-negative 2 (CD27−, IgD−, CD11c+, CD21−(DN2...
Polyclonal B cell activation is a well-described feature of systemic lupus erythematosus (SLE), but the immune mechanisms leading to this activation are unclear. To gain insight into these processes, we extensively characterized the activated peripheral blood B cell populations in SLE. PBMC from lupu...
memory B cell naive B cell repertoire Introduction Antigen-specific immune memory results from the activation of naive B cells. Usually, a naive B cell recognizes an epitope on an antigen using six complementarity determining regions (CDRs) of its immunoglobulin (Ig) heavy (H) and light (L) ...
Differential regulation of activation and differentiation processes in CD4+ T cell populations and their single-cell level heterogeneity cells, the relationship between Treg and non-naive T cells including memory-phenotype T cells (Tmem) and effector T cells (Teff) is not well understood... A Brad...
(Fig. 2a–h). Of interest, we found that Ig-Tg B cells formed GC, memory and PCs even at antigen doses suboptimal for B-cell activation (based on their failure to induce CD69 and CD86 upregulation or surface IgM downregulation,Fig. 2a–d). However, significantly decreased accumulation ...
Interleukin-15 (IL-15), a product of monocytes and other cells, has biological activities similar to those of IL-2, including growth stimulation of activated T cells, induction of cytolytic effector cells, and B-cell costimulation for proliferation and lg production. We report that IL-15 at ...
Hence the activation of naive T cells is crucially dependent on adequate calcitriol levels. WikiMatrix Naive T cells have very low expression of VDR and PLC-γ1. WikiMatrix Initially, naive B cells express only cell-surface IgM and IgD with identical antigen binding regions. WikiMatrix CD28...
To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and the transcription factor NF-κB ...