VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responsesCytokinesLymphocyte activationNaive T cells are known to express the modest level of TLR4 while it is known to go down during TCR activation. However, information towards the ...
peptide complexes it encounters, it exits through the efferent lymphatics, which ultimately drain into thethoracic ductand then back into the blood. If a naïveT celldoes encounter an antigen-presenting cell that expresses an MHC/peptide to which it can bind, it will initiate an activation ...
Activation of naive, memory and effector T cellsActivation of naive, memory and effector T cellsAPC —antigen presenting cellCTL —cytotoxic T lymphocyteCTLA —cytotoxic T lymphocyte-associated antigenDC —dendritic cellHSA —heat stable antigenICAM...
Interleukin-15 (IL-15), a product of monocytes and other cells, has biological activities similar to those of IL-2, including growth stimulation of activated T cells, induction of cytolytic effector cells, and B-cell costimulation for proliferation and lg production. We report that IL-15 at ...
Food allergy poses a significant clinical and public health burden affecting 2–10% of infants. Using integrated DNA methylation and transcriptomic profiling, we found that polyclonal activation of naive CD4+ T cells through the T cell receptor results i
Hence the activation ofnaiveTcellsis crucially dependent on adequate calcitriol levels. WikiMatrix NaiveTcellshave very low expression of VDR and PLC-γ1. WikiMatrix Initially,naiveBcellsexpress only cell-surface IgM and IgD with identical antigen binding regions. ...
Naive CD4+ T cells isolated with the Naive CD4+ T Cell Isolation Kit II can be used when direct labeling of cell surface molecules could interfere with downstream applications, e.g., in studies on naive T helper cell activation and in functional studies of DCs.1, 2 Untouched naive CD4+ ...
Antigen-specific priming of human, naive T cells has been difficult to assess. Owing to the low initial frequency in the naive cell pool of specific T cell precursors, such an analysis has been obscured by the requirements for repeated stimulations and p
These results demonstrate that LFA-1 and CD28 exhibit distinct, nonoverlapping ways to influence T cell activation and suggest that the terms costimulation and signal 2 should be revisited. 展开 关键词: Animals Mice Antigen-Presenting Cells T-Lymphocytes Lymphocytic choriomeningitis virus Calcium ...
Because of this technical limitation, most current knowledge of naive T cell activation is based on the adoptive transfer of large numbers of monoclonal TCR transgenic T cells into histocompatible hosts (Jenkins et al., 2001). Although such systems have proven their use, concerns over the ...