更重要的是,WT B 细胞最终变得独立于自身反应性 B 细胞,能够在自身反应性 B 细胞缺失的情况下维持 GC 反应。 2024年3月22日,美国哈佛医学院Michael C. Carroll在Science Immunology上发表题为“Invasion of spontaneous germinal centers by naive Bcellsis rapid and persistent”的文章。本研究证实自身反应性GC的...
什么是Naïve B cell 与T细胞类似,B细胞也是从干细胞分化而来,通过接触独特的抗原分化后激活。B细胞表面受体BCR与外来抗原结合后发挥下游生物学功能。通常来说,B细胞发育的最后阶段在脾脏中,在那里发育成初始B细胞。这些不被激活的初始B细胞随着血液进入到刺激淋巴器官(SLO)。初始的B细胞更容易捕获病原体,因为SLO的...
Naïve B cells provide an additional path for delivery of IC into the B cell follicles and retention on FDC [31••]. Immune complexes are bound by SCS macrophages and in the presence of complement C3 transferred to naïve B cells in the underlying follicles [31••]. Subsequently...
产品类型:B细胞分选品牌:Miltenyi货号:130-091-150 规格:用于标记 1×10e9 细胞 价格:11371加入购物车 产品介绍 技术参数 相关产品 产品介绍初始B细胞富集试剂盒II用于从人的PBMC中快速有效地分离未经标记的初始B细胞。 详细的分离过程 非B细胞(T细胞,NK细胞,树突状细胞,单核细胞,粒细胞,血小板和类红细胞)和非...
初始B细胞富集试剂盒II用于从人的PBMC中快速有效地分离未经标记的初始B细胞。 详细的分离过程 非B细胞(T细胞,NK细胞,树突状细胞,单核细胞,粒细胞,血小板和类红细胞)和非初始B细胞(记忆B细胞,活化B细胞和浆细胞)被生物素化抗体混合物 CD2,CD14,CD16,CD27,CD36,CD43和CD235a(糖蛋白A)标记。 这些细胞随后用抗...
EasySep™ Human Naive B Cell Enrichment Kit/EasySep™ 人初始B细胞免疫磁珠富集试剂盒产品类型:B细胞分选品牌:STEMCELL Technologies货号:19254 规格:用于标记1*10e9细胞 价格:10336 货号:19254RF 规格:用于标记1*10e9细胞 价格:10872加入购物车 产品介绍 技术参数 相关产品 ...
Niino M; Hirotani M; Miyazaki Y;.Memory and naive B - cell subsets in patients with multiple sclerosis.Neurosci Lett.2009.74-78Niino M, Hirotani M, Miyazaki Y, Sasaki H. Memory and na€ive B-cell subsets in patients with multiple sclerosis. Neurosci Lett 2009; 464:74-8....
Our finding might help to explain old observations on tolerance induction by B cells, identify the mature immunologic as a central functional module of this process, and suggest the use of naive B-cell-primed regulatory T cells, "bTregs," as a useful approach for therapeutic intervention in ...
Deep analysis of B cell activation pathways by our group and others has led to a strong emphasis on the extrafollicular (EF) pathway as a common feature of severe disease14,15,17. Characterized by the induction of T-bet-driven double-negative 2 (CD27−, IgD−, CD11c+, CD21−(DN2...
The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early