Naïve B cells provide an additional path for delivery of IC into the B cell follicles and retention on FDC [31••]. Immune complexes are bound by SCS macrophages and in the presence of complement C3 transferred to naïve B cells in the underlying follicles [31••]. Subsequently...
更重要的是,WT B 细胞最终变得独立于自身反应性 B 细胞,能够在自身反应性 B 细胞缺失的情况下维持 GC 反应。 2024年3月22日,美国哈佛医学院Michael C. Carroll在Science Immunology上发表题为“Invasion of spontaneous germinal centers by naive B cells is rapid and persistent”的文章。本研究证实自身反应性G...
初始B细胞富集试剂盒II用于从人的PBMC中快速有效地分离未经标记的初始B细胞。 详细的分离过程 非B细胞(T细胞,NK细胞,树突状细胞,单核细胞,粒细胞,血小板和类红细胞)和非初始B细胞(记忆B细胞,活化B细胞和浆细胞)被生物素化抗体混合物 CD2,CD14,CD16,CD27,CD36,CD43和CD235a(糖蛋白A)标记。 这些细胞随后用抗...
The Naive B Cell Isolation Kit II was developed for the fast and efficient isolation of untouched naive B cells from human PBMCs. Detailed separation procedure Non-B cells (T cells, NK cells, dendritic cells, monocytes, granulocytes, platelets, and erythroid cells) and non-naive B cells (mem...
Unlike thenaiveBcellsinvolved in the primary immune response the memory B cell response is slightly different. WikiMatrix Recognition by anaiveTcellclone of its cognate antigen results in the initiation of an immune response. WikiMatrix The number of naturally occurring Tregs is very small, encourag...
In germinal centers (GCs) B cells undergo cycles of proliferation and somatic hyper mutation followed by affinity discrimination. Selection of GC B cells expressing high affinity B cell receptors (BCRs) is driven by the ability of B cells to signal through the BCR and extract antigen to ...
We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB...
什么是Naïve B cell 与T细胞类似,B细胞也是从干细胞分化而来,通过接触独特的抗原分化后激活。B细胞表面受体BCR与外来抗原结合后发挥下游生物学功能。通常来说,B细胞发育的最后阶段在脾脏中,在那里发育成初始B细胞。这些不被激活的初始B细胞随着血液进入到刺激淋巴器官(SLO)。初始的B细胞更容易捕获病原体,因为SLO的...
The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early
Between 12% and 88% of the responding germinal centre B cell clones overlapped with B cells detected among early circulating plasmablasts. These shared B cell clones had high frequencies of somatic hypermutation and encoded broadly cross-reactive monoclonal antibodies. By contrast, vaccine-induced B ...