Transcriptional signatureResting memory CD4 T cellsHIV reservoirViral controlThe HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component harboring latent proviruses. This is the first study analyzing the ...
Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+T-cells remain unclear. Previously we have shown ...
Unlike memory CD8 T cells and plasma cells, which reside in bone marrow niches, it had been presumed that memory CD4 T cells constantly circulate in the body for surveillance. Now, Tokoyoda and colleagues show that memory CD4 T cells do in fact reside and rest in the bone marrow, where ...
Long-lived resting memory CD4+ T cells (TCM) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-TCM cells are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1, and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that com...
名称:EasySep™ 人静息CD4+T细胞分选试剂盒 品牌:STEMCELL 产品描述:Immunomagnetic negative selection kit 购买数量: 立即购买 产品信息 The EasySep™ Human Resting CD4+ T Cell Isolation Kit is designed to isolate resting CD4+ T cells from fresh or previously frozen human peripheral blood mononuclear ...
Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells Homeostatic proliferation ensures the longevity of central memory T-cells by inducing cell proliferation in the absence of cellular differentiation or acti... A Bosque,M Famiglietti,AS Weyrich,....
In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM memory Th cells. Here we review recent evidence that CD69 and CD49b control homing of memory Th cell precursors to the BM. During the effector phase of an immune response, ...
Although we also found very few effector memory or dividing cells within the sorted resting CD4 T cell population, future studies could sort even more highly refined resting CD4 T cell populations or investigate other anatomical sites to evaluate this further. A second po...
This might be due to distinct efficiencies of nuclear and cytoplasmic exchange among different cell types, given that Vpx-mediated SAMHD1 degradation is dependent on its nuclear export [11]. Furthermore, Vpx increases HIV-1 infection of all resting CD4+ T-cell subsets (naïve, central memory ...
Both CD80 and CD86 efficiently costimulated alloresponses by unseparated peripheral blood CD4 T cells; however, CD86 was substantially inferior in costimulating alloresponses by separated memory T cells, and completely incompetent in costimulating three human T cell clones. Furthermore,...