Transcriptional signatureResting memory CD4 T cellsHIV reservoirViral controlThe HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component harboring latent proviruses. This is the first study analyzing the ...
Unlike memory CD8 T cells and plasma cells, which reside in bone marrow niches, it had been presumed that memory CD4 T cells constantly circulate in the body for surveillance. Now, Tokoyoda and colleagues show that memory CD4 T cells do in fact reside and rest in the bone marrow, where ...
Taken together, we conclude that CD4+ T cells mediate obesity memory and promote weight regain. Cellular & Molecular Immunology advance online publication, 19 June 2017; doi:10.1038/cmi.2017.36 Keywords: CD4+ T cell; immunodeficiency; metabolism; obesity memory; weight regain INTRODUCTION Obesity is...
名称:EasySep™ 人静息CD4+T细胞分选试剂盒 品牌:STEMCELL 产品描述:Immunomagnetic negative selection kit 购买数量: 立即购买 产品信息 The EasySep™ Human Resting CD4+ T Cell Isolation Kit is designed to isolate resting CD4+ T cells from fresh or previously frozen human peripheral blood mononuclear ...
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation The latent reservoir of HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1 infection. Eradication strategies involve reactiv...
CD4+ T-Cell Memory CD4+ T cells differentiate and expand during an immune response to a particular invasion. Once infection is cleared, memory Th cells are generated over time following the death of the majority of effector cells. These memory cells can quickly respond to a secondary infection...
resting CD4 T cells HIV-1 nuclear import Vpx Research topic(s) CP: Immunology CP: Microbiology Introduction CD4 T cells are the major targets of HIV-1 in vivo, and their permissivity to productive infection is dictated by their activation state. The CD4 T cell repertoire residing within lymph...
Several populations of memory T cells have been described that differ in their migration and function. In this study, we have identified a unique subset of... Bromley,K Shannon - 《Journal of Immunology》 被引量: 127发表: 2013年 CD49b/CD69-Dependent Generation of Resting T Helper Cell Me...
1 infection can persist despite ART in the resting CD4⁺ T cell reservoir of hu-Rag2⁻/⁻ γ(c)⁻/⁻ mice. This model will allow rapid preliminary assessments of novel eradication approaches and combinatorial strategies that may be challenging to perform in the NHP model or in humans...
Therefore, the requirement for CD4 help in CD8 T cell memory extends to homeostatic parameters that ensure the maintenance and competitive fitness of memory clones.doi:10.1002/eji.200324231P?l JohansenPanagiota StamouRicardo?E. TasconDouglas?B. Lowrie...