Latent HIV-1 infection of resting CD4 + T cells provides a long-lived reservoir of viral persistence in patients on antiretroviral therapy (ART). Intensive research into the mechanisms of HIV-1 latency has led to the identification of numerous potential therapeutic targets that might be exploited ...
Conclusion Vpx allows the non-productive infection of resting CD4+ T cells, but does not confer HIV-2 with the ability to efficiently infect MDDCs. In these cells, an entry defect prevents viral fusion and reverse transcription independently of SAMHD1. We propose that HIV-2, like HIV-1, ...
resting CD4 T cells HIV-1 nuclear import Vpx Research topic(s) CP: Immunology CP: Microbiology Introduction CD4 T cells are the major targets of HIV-1 in vivo, and their permissivity to productive infection is dictated by their activation state. The CD4 T cell repertoire residing within lymph...
名称:EasySep™ 人静息CD4+T细胞分选试剂盒 品牌:STEMCELL 产品描述:Immunomagnetic negative selection kit 购买数量: 立即购买 产品信息 The EasySep™ Human Resting CD4+ T Cell Isolation Kit is designed to isolate resting CD4+ T cells from fresh or previously frozen human peripheral blood mononuclear ...
cells and tissue reservoirs (e.g., lymph node, spleen, bone marrow) following HIV-1 infection with the CCR5-tropic JR-CSF strain and suppression of viremia by ART. Replication-competent virus was recovered from pooled resting CD4⁺ T cells in 7 of 16 mice, with a median frequency of ...
Resting human CD4 T cells are highly resistant to transfection or infection with lentiviral vectors derived from the human immunodeficiency virus. We now describe a flexible and efficient approach involving virus-like particles containing simian immunodeficiency virus lentiviral gene product protein X and ...
induced in HIV-l-exposed, resting CD4+T cells subsequent tO signaling through homing receptors iS Fas/Fas ligand.mediated-J Leukoc BioI 2007;8 1 f1):... Jiaxiang,Ji,Jenny,... - 《Journal of Leukocyte Biology》 被引量: 12发表: 2007年 Infliximab treatment induces apoptosis of lamina propria...
Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+
Resting CD4+ T-cells are critical for establishing HIV-1 reservoirs. It has been known for over two decades that resting CD4+ T-cells are refractory to HIV-1 infection, but the underlying mechanisms are not fully understood. Compared with activated CD4+ T-cells that support HIV-1 infection,...