The HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component harboring latent proviruses. This is the first study analyzing the transcriptional profile of Trm cells, in two well-characterized groups of ...
Long-lived resting memory CD4+ T cells (TCM) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-TCM cells are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1, and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that com...
Long-lasting memory- resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia. Blood 2002; 99:2131-7.Paroli M, Accapezzato D, Francavilla V, Insalaco A, Plebani A, Balsano F, et al. Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked...
Resting CD4+ effector memory T cells are pre- cursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function. Arthritis Res Ther 2008; 10:R36.Brennan FM, Smith NM, Owen S, et al. Resting CD4+ effector memory T cells are precursors of bystander-...
Boursalian, T. E., and K. Bottomly. 1999. Stability of naive and memory phe- notypes on resting CD4 T cells in vivo. J. Immunol. 162:9.Boursalian T.E. and Bottomly K. 1999. Stability of naive and memory phenotypes on resting CD4 T cells in vivo. Jounral of Immunol. 162:9-...
Down-modulation of CD62L and upregulation of CD69 and on productively infected naïve and memory resting CD4 T cells.Benjamin, TrinitéChi, N. ChanCaroline, S. LeeSaurabh, MahajanYang, LuoMark, A. MuesingJoy, M. FolkvordMichael, Pham...
DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4 + T cells: a potential role in a cure strategy for HIV-1 infectiondoi:10.1080/15548627.2019.1569950Grant R. CampbellStephen A. Spector
ObjectiveResting CD4+ T cells are major reservoirs of latent HIV-1 infection, and may be formed during the early phase of the infection. Although CCR5-tropic (R5) HIV-1 is highly transmissible during the early phase, newly infected individuals have usually been exposed to a mixture of R5 ...
This tetramer-enriched approach detected BCG-elicited resting memory P65-specific CD4 T cells at a frequency of 2-3/10,000 in PBL.Huiyong, WeiRichard, WangZhuqing, YuanCrystal, Y. ChenDan, HuangLisa, HallidayWeihua, ZhongGucheng, Zeng