molecular sciences relaxin 2/rxfp1 signaling induces cell invasion via the β-catenin pathway in endometrial cancer M Fue,Y Miki,K Takagi,... 被引量: 0发表: 2019年 Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2 The hormone relaxin inhibits ...
TGFbeta Signaling in Growth Control, Cancer, and Heritable Disorders. Focuses on the role of transforming growth factor (TGF)-beta in the regulation of cell growth and differentiation. Assembly of receptor complexes activatin... Massague,Joan,Blain,... - 《Cell》 被引量: 3310发表: 2000年 ...
Hyperplasia precedes, and is a prerequisite for, prostate cancer in men and male dogs [4]. It begins with a marked remodelling of the connective framework of the gland and significant angiogenesis [5]. Therefore, experiments were done to investigate the possibility that relaxin of prostatic ...
Here, we tested the hypothesis that the effects of RLX on Nav1.5 and fibrosis are mediated by canonical Wnt signaling. While RLX and Wnt signaling have been investigated in models of cancer18,19,20, there is no work on the interactions of the RLX and Wnt pathways in adult heart and ‘he...
Tirado-Rodriguez B, Ortega E, Segura-Medina P, Huerta-Yepez S: TGF- beta: an important mediator of allergic disease and a molecule with dual activity in cancer development. J Immunol Res 2014;2014:318481. 47. Szefel J, Kruszewski WJ, Ciesielski M, Szajewski M, Kawecki K, Jankun J,...
Relaxin is an antifibrotic peptide hormone previously assumed to directly reverse the activation of hepatic stellate cells for liver fibrosis resolution. Using nanoparticle-mediated delivery, here we show that, although relaxin gene therapy reduces liver
Thus, perturbations in one pathway will most likely influence others. It is essential to adopt a systematic approach based on clues from animal models to reveal the role of TGFβ signaling in the pathogenesis of human testicular dysgenesis and cancer. In the human testis, activin and inhibin ...
Mutations in p53 occur at a rate of approximately 70% in hormone-refractory prostate cancer (CaP), suggesting that p53 mutations facilitate the progression of CaP to androgen-independent (AI) growth. We have previously reported that transfection of p53 gain of function mutant alleles into LNCaP, ...
Investigation of the similar but not identical functioning of the related receptor RXFP2 is valuable as a comparison to RXFP1 and in its own right as a potential future therapeutic target for conditions including cryptorchidism, osteoporosis and cancer. Additionally H2 relaxin is able to bind and ...
International Journal of Molecular Sciences Article Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer Misaki Fue 1, Yasuhiro Miki 1,* ID , Kiyoshi Takagi 2, Chiaki Hashimoto 3, Nobuo Yaegashi 3, Takashi Suzuki 2 and Kiyoshi Ito 1 1 Department of...