regulatory T cellsspecificitytumor microenvironmentThe adaptive immune system is modulated by an important subset of CD4+ T lymphocytes called regulatory T (Treg) cells that function in maintaining immune homeostasis by preventing excessive immune activation. Both deficiency and overactivation of Treg cell...
Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting anti-tumour immunity. TReg cells have multiple mechanisms at their dis...
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat. Med. 15, 192–199 (2009). Article CAS PubMed Google Scholar Shi, L. et al. Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 54, 1527–...
Chapter 15 – Regulatory T cells in Tumor Immunity: Role of Toll-Like ReceptorsThis chapter discusses how the toll-like receptor (TLR) signaling is linked to the functional control of Tregs, and reviews the new tactics to improve cancer therapy by relieving the Treg-mediated suppression of...
Tumor-dervied gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr ... J Ye,C Ma,E Hsueh,... - 《Cancer Research》 被引...
One possibility is alterations in the highly suppressive T cell subset, regulatory T cells (Tregs). CD25Foxp3Tregs regulate nearly all aspects of the immune response, making them a plausible candidate for the impaired immunity in obese mice and likely obese humans. Diet-induced obese and lean ...
How do Regulatory T Cells Work? CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens... A Corthay - 《Scandinavian Journal of Immunology》 被引量: 655发表: 2009年 加载更多来源...
Depression and immunity: A role for T cells? Data indicate that T regulatory cells may also play a role in depression through downregulation of chronic inflammatory responses. Based on the notion that ... AH Miller - 《Brain Behavior & Immunity》 被引量: 249发表: 2010年 The role of Foxp3...
Dendritic cell|[ndash]|regulatory T-cell interactions control self-directed immunity 来自 Nature 喜欢 0 阅读量: 28 作者:M Dürr,H Doster,A Melms,F Bischof,C Lange 摘要: Immunology and Cell Biology focuses on the general functioning of the immune system in its broadest sense, with a ...
to the CD4+CD25+ T cell subset. These cells act by suppressing adaptive and possibly also innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T cells are cell-contact dependent but a role for soluble ...