迟洪波教授发表了重磅综述,进一步提出了 T 细胞免疫的第四信号——营养物质 2024年4月,《Cell》杂志发表了题为Principles and therapeutic applications of adaptive immunity的综述。由Hongbo Chi、Marion Pepper和Paul G. Thomas联合撰写,深入地探讨了适应性免疫(Adaptive immunity)的原理及其在治疗领域的应用。适应性免...
T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection. ...
naïve T celleffector T cellimmune synapseco-stimulatory signalsCTLT H 1T H 2T H 7T REGOnce alerted by the innate immune system to the presence of a pathogen or a cellular abnormality, the adaptive immune system responds by activating and expanding antigen-specific B and T lymphocytes. ...
作为免疫治疗的一个重要分支,过继性细胞治疗(adoptive cell transfer,ACT)是全球范围内研究最广泛、我国应用最普遍的一类免疫治疗技术。其中T细胞受体(T cell receptor,TCR)基因工程化的 T 细胞(TCR-T细胞)在实体肿瘤治疗的临床试验中展示出了较好的治疗效果以及应用潜力。为了令大家对TCR-T细胞治疗有更加全面的认识,...
作为免疫治疗的一个重要分支,过继性细胞治疗(adoptive cell transfer,ACT)是全球范围内研究最广泛、我国应用最普遍的一类免疫治疗技术。其中T细胞受体(T cell receptor,TCR)基因工程化的 T 细胞(TCR-T细胞)在实体肿瘤治疗的临床试验中展示出了较好的治疗效果以及应用潜力。为了令大家对TCR-T细胞治疗有更加全面的认识,...
+T cells. These MP cells rapidly produce IFN-γ in response to IL-12, which provides host resistance againstToxoplasma gondiiinfection in the absence of cognate antigen recognition41. Thus, IL-12 appears to be an important inflammatory mediator of bystander T-cell responses in type-1 immunity....
这就启发了过继细胞(adoptive cell transfer,ACT)治疗肿瘤的思路,即从癌症患者的外周血中获取免疫细胞,借助于细胞因子的刺激作用,经体外培养扩增后回输给原患者。这种方法在1984年开始用于临床探索性研究中,当时这种技术手段被命名为淋巴因子激活的杀伤细胞(lymphokine-activated killer cells,LAK)疗法[2]。随后,又有...
Figure 1. Role of T cells in adaptive immune response. Here we present an example of the content from the T Cell Stimulation and Proliferation eLearning course. Role of T Cells T cells are primarily ...
Demonstration of a Cell-Mediated Immune Response in Melioidosis. Melioidosis is a bacterial infection caused by Burkholderia pseudomallei. The aim of this study was to determine whether a cell-mediated adaptive immune re... Ketheesan,Natkunam,Barnes,... - 《Journal of Infectious Diseases》 被...
骨髓间充质干细胞(mesenchymal stromal cell,MSCs)被报道可有效抑制免疫细胞活化,包括T淋巴细胞、B淋巴细胞,巨噬细胞,自然杀伤细胞,DC细胞和其他免疫细胞等。研究结果显示在高脂饮食诱导的NAFLD小鼠模型中移植MSCs,可抑制脾脏CD4+干扰素-γ...