T cells are major players in the adaptive immune response to pathogens. They express clonally distributed, highly polymorphic antigen receptors that enable them to recognize cell-associated antigen. Upon antigen recognition, T cells undergo clonal amplification and progressively acquire effector functions, ...
The part of theimmune responsethat can target germs precisely and provide long-term protection is called theadaptive immune response. Two types of white blood cell are important in this: T cells and B cells. These cells work together to orchestrate a targeted immuneresponse. But the way they ...
Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017.Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, ... S Ravens,C Schultze-Florey,S Raha,... - 《Nature Immunolo...
Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major Design strategy of both feedback gains and adaptation gains for an adaptive full-order observer is a necessary issue to assure the stability and the tracki... S ...
Activated B cells migrate to the T-B border11,12,13 or interfollicular zone14 to acquire T cell help, undergo CD40L-dependent proliferation15 and differentiate into either extrafollicular short-lived plasma cells, or follicular germinal centre (GC) B cells. Here, we use intravital two-photon ...
T cells are immune cells in adaptive immunity responsible for the initiation and orchestration of antigen-specific immune responses. T cells migrate throughout the body to perform immune surveillance and to mount immune responses against pathogens and tumors1, 2. To efficiently survey large areas of...
Why bears know when it’s trash day, coyotes learned to look both ways before crossing the street, and raccoons can untie bungee cords.
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cells represents a hallmark of initiation of acquired immunity. T cell activation is initiated at T cell receptor (TCR) microclusters (MCs), in which TCRs and signaling molecules assemble at the ...
marked by IgA + cells, can cause delayed cognitive dysfunction in mice and that a similar adaptive immune response occurs in the brains of some human stroke patients that suffer from vascular dementia. The stimuli which trigger B-lymphocyte activation following stroke, and their target antigens, ...
The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO+ T cells reside in the fetal intestine. Here we combined functional assays with mass cytometry, single-cell RNA sequencing and high-throughput T cell antigen receptor (TCR) sequencing to characterize the CD4+ ...