stimulation14,15. Interestingly, the TCR-independent activation of CD4+T cells has primarily been observed in memory (CD44high) cells, while naïve (CD44low) cells exhibit lower reactivity13,14,15. Thus, it appears that cytokines and innate receptors, such as Toll-like receptors (TLRs), can...
The T cell as a bridge between innate and adaptive immune systems: Implications for the kidney. The immune system is classically divided into innate and adaptive components with distinct roles and functions. T cells are major components of the adaptive immune system. T cells are firmly established...
Th17 T cells: linking innate and adaptive immunity. Sem Immunol 2007;19:353-61.Stockinger, B., Veldhoen, M., and Martin, B. (2007). Th17 T cells: linking innate and adaptive immunity. Semin. Immunol. 19, 353-361.Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and...
Y. Regulatory T cells: mechanisms of differentiation and function. Annu Rev. Immunol. 30, 531–564 (2012). Article CAS PubMed PubMed Central Google Scholar Annunziato, F., Romagnani, C. & Romagnani, S. The 3 major types of innate and adaptive cell-mediated effector immunity. J. ...
T cells are primarily involved in adaptive rather than innate immune responses. Adaptive immunity is mediated by both CD4 and CD8-positive T cells and by antibody-producing B cells. Adaptive immunity is a...
21、 activation could diminishchronic pathological immune responsesGeneration and conversion of Treg cells in the tumor microenvironmentTumor cells not only provide antigenic stimulation for T cell activation but also interact with tumor-infiltrating innate immune cells to secrete crucial cytokines for 22、...
γδ T cells link innate and adaptive immune responses focus on human Vγ9/Vδ2 and Vδ1 T cells. Chem Immunol Allergy Basel. 2005;86:151–83. Article CAS Google Scholar Padovan E, Casorati G, Dellabona P, Meyer S, Brockhaus M, Lanzavecchia A. Expression of two T cell receptor ...
2024年4月28日,休斯顿卫理会医院研究所(Houston Methodist Research Institute)的科学家们在Advanced Science发表了题为T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells的研究论文【5】。该研究发现...
Human Vγ9Vδ2 T cells: From signals to functions Human Vγ9Vδ2 T cells, a major innate-like peripheral T cell subset, are thought to play in vivo a key role in innate and adaptive immune responses to inf... S Nedellec,M Bonneville,E Scotet - 《Seminars in Immunology》 被引量:...
innate antiviral response along with hyperinflammation may be one of the causes of the COVID-19 severity [46]. In addition to decreasing the number of T cells, SARS-CoV-2 infection also increases the depletion of effector T cells, thus decreasing the immune response against the virus [47]....