Much interest has been raised in harnessing the immunomodulatory effects of regulatory T cells (TREGs) to treat autoimmune disorders. There is evidence that TREGs stimulate the production of interleukin 17 (IL-1
A type of immune cell called a CD8 T cell, which usually kills disease-causing agents, has been found instead to suppress self-reactive immune cells, thereby offering protection against an autoimmune disease in mice. By Hye-Jung Kim & Harvey Cantor ...
In recent years, the understanding of regulatory T cell (Tregcell) biology has expanded considerably. Key observations have challenged the traditional definition of Tregcells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic...
regulatory T cellsRegulatory T cells (Tregs) are critical for peripheral immune tolerance and homeostasis, and altered Treg behavior is involved in many pathologies, including autoimmunity and cancer. The expression of the transcription factor FoxP3 in Tregs is fundamental to maintaining their stability...
Regulatory T cells (Tregs) play a dominant role in the regulation of immune responses. Quantitative and/or qualitative abnormalities of Tregs were observed in patients with autoimmune diseases and therapeutic interventions focusing Tregs are an attractive new target with the potential to cure these diso...
Regulatory t cells are key in maintaining self-tolerance and immune cell homeostasis, as well as regulating immune responses responsible for autoimmune diseases.
At the present time, regulatory T cells (Tregs) are an integral part of immunology but the route from discovery of "suppressive" lymphocytes in the 1980s to the current established concept of Tregs almost 20 years later has been a rollercoaster ride. Tregs are essential for maintaining self-...
Regulatory T-cells (Tregs) are a type of white blood cell that suppresses the body’s immune response and prevents unnecessary inflammation. Tregs are part of the immune system and can enter the brain and the spinal cord to reduce neuroinflammation....
Autoimmune disease: A human antibody selectively targets regulatory T cellsAt low doses, IL-2 induces the proliferation and functional activation of regulatory T (T reg ) cells, which suppress autoimmune responses and transplant rejection in mouse models. In a new paper in Nature Medicine , ...
M. Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J. Neuroimmunol. 193, 1–11 (2008). Article PubMed Google Scholar Korn, T. Foxp3+ regulatory T cells in the central nervous system and other nonlymphoid tissues. Eur. J. Immunol. 53, e2250227 (2023...