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It is possible that antigen-specific regulatory T (TReg) cells can be induced to prevent or treat autoimmune diseases. The effector functions of antigen-induced TRegcells cannot be defined uniformly and have to be analysed in relation to the disease process that they suppress. ...
During the past 10years, CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been extensively studied for their function in autoimmune disease. This review summarizes the evidence for a role of Treg in suppression of innate and adaptive immune responses in experimental models of autoimmunity in...
Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymph...
Impairment of CD4+CD25+ regulatory T-cells in autoimmune liver disease Background/AimsCD4+ lymphocytes constitutively expressing the IL-2-receptor 伪-chain (CD25) regulate the activation of CD4 and CD8 autoreactive T-cells by ... MS Longhi,M Yun,DP Bogdanos,... - 《Journal of Hepatology》...
Regulatory T-cells (Tregs) are a type of white blood cell that suppresses the body’s immune response and prevents unnecessary inflammation. Tregs are part of the immune system and can enter the brain and the spinal cord to reduce neuroinflammation....
Regulatory T cells (Tregs) are CD4+ T cells that can suppress immune responses by effector T cells, B cells and innate immune cells. This review discusses the role that Tregs play in murine models of immune-mediated renal diseases and acute kidney injury and in human autoimmune kidney disease...
Therapeutic potential of TGF-β-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases. Xiaohui Zhou,Ning Kong,Hejian Zou,... - 《Autoimmunity》 - 2011 - 被引量: 94 Circulating CD4+CD25+ Regul...
Regulatory T cells control the reactivity of potentially harmful, self-reactive T cells and prevent autoimmune diseases. Significant progress has been made in the identification, derivation, and mechanism of action of T regulatory cells, previously called suppressor T cells. Heterogeneous T regulatory su...